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TargetG-protein Coupled Receptor 54
LigandBDBM50082075
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1474616
EC50 2.5±n/a nM
Citation Beltramo, MRobert, VGalibert, MMadinier, JBMarceau, PDardente, HDecourt, CDe Roux, NLomet, DDelmas, AFCaraty, AAucagne, V Rational design of triazololipopeptides analogs of kisspeptin inducing a long-lasting increase of gonadotropins. J Med Chem58:3459-70 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
G-protein Coupled Receptor 54
Name:G-protein Coupled Receptor 54
Synonyms:G-protein coupled receptor 54 (GPR54) | Hypogonadotropin-1 | KiSS-1R | Kisspeptins receptor | Metastin receptor | hOT7T175
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:42613.79
Organism:Homo sapiens (Human)
Description:Binding assay was performed using membranes from the CHO cell transfectants.
Residue:398
Sequence:
MHTVATSGPNASWGAPANASGCPGCGANASDGPVPSPRAVDAWLVPLFFAALMLLGLVGN
SLVIYVICRHKPMRTVTNFYIANLAATDVTFLLCCVPFTALLYPLPGWVLGDFMCKFVNY
IQQVSVQATCATLTAMSVDRWYVTVFPLRALHRRTPRLALAVSLSIWVGSAAVSAPVLAL
HRLSPGPRAYCSEAFPSRALERAFALYNLLALYLLPLLATCACYAAMLRHLGRVAVRPAP
ADSALQGQVLAERAGAVRAKVSRLVAAVVLLFAACWGPIQLFLVLQALGPAGSWHPRSYA
AYALKTWAHCMSYSNSALNPLLYAFLGSHFRQAFRRVCPCAPRRPRRPRRPGPSDPAAPH
AELLRLGSHPAPARAQKPGSSGLAARGLCVLGEDNAPL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50082075
NameBDBM50082075
Synonyms:CHEMBL3422406
TypeSmall organic molecule
Emp. Form.C63H83N17O15
Mol. Mass.1318.438
SMILESCC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O |r|
Structure
n/a