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Target
Hematopoietic prostaglandin D synthase
Ligand
BDBM50084152
Substrate
n/a
Meas. Tech.
ChEMBL_1477162 (CHEMBL3428602)
EC50
74±n/a nM
Citation
 Edfeldt, F; Evenäs, J; Lepistö, M; Ward, A; Petersen, J; Wissler, L; Rohman, M; Sivars, U; Svensson, K; Perry, M; Feierberg, I; Zhou, XH; Hansson, T; Narjes, F Identification of indole inhibitors of human hematopoietic prostaglandin D2 synthase (hH-PGDS). Bioorg Med Chem Lett 25:2496-500 (2015) [PubMed]  Article 
Target
Name:
Hematopoietic prostaglandin D synthase
Synonyms:
GSTS | Glutathione-dependent PGD synthetase | Glutathione-requiring prostaglandin D synthase | H-PGDS | HPGDS | HPGDS_HUMAN | Hematopoietic prostaglandin D synthase | Hematopoietic prostaglandin D synthase (H-PGDS) | Hematopoietic prostaglandin D synthase (HPGDS) | PGDS | PTGDS2 | Prostaglandin D | Prostaglandin D Synthase
Type:
Enzyme
Mol. Mass.:
23341.07
Organism:
Homo sapiens (Human)
Description:
The protein was expressed in E. coli strain BL21(DE3) with an N-terminal 6-His tag.
Residue:
199
Sequence:
MPNYKLTYFNMRGRAEIIRYIFAYLDIQYEDHRIEQADWPEIKSTLPFGKIPILEVDGLTLHQSLAIARYLTKNTDLAGNTEMEQCHVDAIVDTLDDFMSCFPWAEKKQDVKEQMFNELLTYNAPHLMQDLDTYLGGREWLIGNSVTWADFYWEICSTTLLVFKPDLLDNHPRLVTLRKKVQAIPAVANWIKRRPQTKL
  
Inhibitor
Name:
BDBM50084152
Synonyms:
CHEMBL3425949
Type:
Small organic molecule
Emp. Form.:
C22H20N6O3
Mol. Mass.:
416.4326
SMILES:
CC(C)(O)c1nc(no1)-c1ccc(CNC(=O)c2cnc(nc2)-c2ccccn2)cc1
Structure:
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