Reaction Details Report a problem with these data
Target
Patatin-like phospholipase domain-containing protein 2
Ligand
BDBM50084887
Substrate
n/a
Meas. Tech.
ChEMBL_1476694 (CHEMBL3428915)
IC50
130000±n/a nM
Citation
 Mayer, N; Schweiger, M; Melcher, MC; Fledelius, C; Zechner, R; Zimmermann, R; Breinbauer, R Structure-activity studies in the development of a hydrazone based inhibitor of adipose-triglyceride lipase (ATGL). Bioorg Med Chem 23:2904-16 (2015) [PubMed]  Article 
Target
Name:
Patatin-like phospholipase domain-containing protein 2
Synonyms:
Adipose triglyceride lipase | Atgl | Desnutrin | PLPL2_MOUSE | Patatin-like phospholipase domain-containing protein 2 | Pnpla2
Type:
PROTEIN
Mol. Mass.:
53655.79
Organism:
Mus musculus
Description:
ChEMBL_109612
Residue:
486
Sequence:
MFPRETKWNISFAGCGFLGVYHIGVASCLREHAPFLVANATHIYGASAGALTATALVTGACLGEAGANIIEVSKEARKRFLGPLHPSFNLVKTIRGCLLKTLPADCHERANGRLGISLTRVSDGENVIISHFSSKDELIQANVCSTFIPVYCGLIPPTLQGVRYVDGGISDNLPLYELKNTITVSPFSGESDICPQDSSTNIHELRVTNTSIQFNLRNLYRLSKALFPPEPMVLREMCKQGYRDGLRFLRRNGLLNQPNPLLALPPVVPQEEDAEEAAVVEERAGEEDQLQPYRKDRILEHLPARLNEALLEACVEPKDLMTTLSNMLPVRLATAMMVPYTLPLESAVSFTIRLLEWLPDVPEDIRWMKEQTGSICQYLVMRAKRKLGDHLPSRLSEQVELRRAQSLPSVPLSCATYSEALPNWVRNNLSLGDALAKWEECQRQLLLGLFCTNVAFPPDALRMRAPASPTAADPATPQDPPGLPPC
  
Inhibitor
Name:
BDBM50084887
Synonyms:
CHEMBL3427346
Type:
Small organic molecule
Emp. Form.:
C17H23N3
Mol. Mass.:
269.3846
SMILES:
C1CCC(\C=N\N2CCN(CC2)c2ccccc2)=CC1 |c:19|
Structure:
Search PDB for entries with ligand similarity: