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Target
Voltage-dependent L-type calcium channel subunit alpha-1C
Ligand
BDBM50088387
Substrate
n/a
Meas. Tech.
ChEMBL_1479077 (CHEMBL3436053)
IC50
7.1±n/a nM
Citation
 Wisniowska, B; Mendyk, A; Fijorek, K; Glinka, A; Polak, S Predictive model for L-type channel inhibition: multichannel block in QT prolongation risk assessment. J Appl Toxicol 32:858-66 (2012) [PubMed]  Article 
Target
Name:
Voltage-dependent L-type calcium channel subunit alpha-1C
Synonyms:
CAC1C_CAVPO | CACH2 | CACH2 | CACN2 | CACNA1C | CACNL1A1 | CCHL1A1 | Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle | Voltage-dependent L-type calcium channel subunit alpha-1C | Voltage-gated calcium channel subunit alpha Cav1.2
Type:
PROTEIN
Mol. Mass.:
19518.62
Organism:
Cavia porcellus
Description:
ChEMBL_106600
Residue:
169
Sequence:
FQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKRAPESEPSNSTEGETPCGSSFAVFY
  
Inhibitor
Name:
BDBM50088387
Synonyms:
Clevidipine | Clevidipine butyrate | Cleviprex
Type:
Small organic molecule
Emp. Form.:
C21H23Cl2NO6
Mol. Mass.:
456.316
SMILES:
CCCC(=O)OCOC(=O)C1=C(C)NC(C)=C(C1c1cccc(Cl)c1Cl)C(=O)OC |c:10,15|
Structure:
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