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Target
UDP-glucuronosyltransferase 1A9
Ligand
BDBM50088499
Substrate
n/a
Meas. Tech.
ChEMBL_1493081 (CHEMBL3529803)
Ki
1651000±n/a nM
Citation
 Fedejko-Kap, B; Bratton, SM; Finel, M; Radominska-Pandya, A; Mazerska, Z Role of human UDP-glucuronosyltransferases in the biotransformation of the triazoloacridinone and imidazoacridinone antitumor agents C-1305 and C-1311: highly selective substrates for UGT1A10. Drug Metab Dispos 40:1736-43 (2012) [PubMed]  Article 
Target
Name:
UDP-glucuronosyltransferase 1A9
Synonyms:
GNT1 | UD19_HUMAN | UDP-glucuronosyltransferase 1-9 | UDP-glucuronosyltransferase 1-I | UDP-glucuronosyltransferase 1A9 | UDPGT 1-9 | UGT-1I | UGT1 | UGT1*9 | UGT1-09 | UGT1.9 | UGT1A9 | UGT1I | lugP4
Type:
PROTEIN
Mol. Mass.:
59953.97
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1489266
Residue:
530
Sequence:
MACTGWTSPLPLCVCLLLTCGFAEAGKLLVVPMDGSHWFTMRSVVEKLILRGHEVVVVMPEVSWQLGRSLNCTVKTYSTSYTLEDLDREFKAFAHAQWKAQVRSIYSLLMGSYNDIFDLFFSNCRSLFKDKKLVEYLKESSFDAVFLDPFDNCGLIVAKYFSLPSVVFARGILCHYLEEGAQCPAPLSYVPRILLGFSDAMTFKERVRNHIMHLEEHLLCHRFFKNALEIASEILQTPVTEYDLYSHTSIWLLRTDFVLDYPKPVMPNMIFIGGINCHQGKPLPMEFEAYINASGEHGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH
  
Inhibitor
Name:
BDBM50088499
Synonyms:
CHEMBL329092
Type:
Small organic molecule
Emp. Form.:
C18H19N5O2
Mol. Mass.:
337.3758
SMILES:
CN(C)CCCNc1ccc2nnn3c2c1c(=O)c1cc(O)ccc31
Structure:
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