Target
Mitogen-activated protein kinase 3
Ligand
BDBM50089082
Substrate
n/a
Meas. Tech.
ChEMBL_1497089 (CHEMBL3580222)
IC50
23±n/a nM
Citation
 Awadallah, FMAbou-Seri, SMAbdulla, MMGeorgey, HH Design and synthesis of potent 1,2,4-trisubstituted imidazolinone derivatives with dual p38aMAPK and ERK1/2 inhibitory activity. Eur J Med Chem 94:397-404 (2015) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 3
Synonyms:
ERK1 | ERK1/ERK2 | Extracellular signal-regulated kinase 1 | Extracellular signal-regulated kinase 1 (ERK1) | MAP kinase ERK1 | MAPK3 | MAPK3/MAPK7 | MK03_HUMAN | Mitogen-activated protein kinase | Mitogen-activated protein kinase 3 | PRKM3
Type:
Protein
Mol. Mass.:
43136.58
Organism:
Homo sapiens (Human)
Description:
curated by PDB 4QTB
Residue:
379
Sequence:
MAAAAAQGGGGGEPRRTEGVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPKERLKELIFQETARFQPGVLEAP
  
Inhibitor
Name:
BDBM50089082
Synonyms:
CHEMBL3577636
Type:
Small organic molecule
Emp. Form.:
C31H25N3O4
Mol. Mass.:
503.5479
SMILES:
COc1ccc(cc1)N1C(=O)\C(=C\c2ccc(OCC(=O)Nc3ccccc3)cc2)N=C1c1ccccc1 |c:33|
Structure:
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