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Target
Tyrosine-protein kinase Fyn
Ligand
BDBM50089570
Substrate
n/a
Meas. Tech.
ChEMBL_1497041 (CHEMBL3580016)
Ki
1485±n/a nM
Citation
 Tintori, C; La Sala, G; Vignaroli, G; Botta, L; Fallacara, AL; Falchi, F; Radi, M; Zamperini, C; Dreassi, E; Dello Iacono, L; Orioli, D; Biamonti, G; Garbelli, M; Lossani, A; Gasparrini, F; Tuccinardi, T; Laurenzana, I; Angelucci, A; Maga, G; Schenone, S; Brullo, C; Musumeci, F; Desogus, A; Crespan, E; Botta, M Studies on the ATP Binding Site of Fyn Kinase for the Identification of New Inhibitors and Their Evaluation as Potential Agents against Tauopathies and Tumors. J Med Chem 58:4590-609 (2015) [PubMed]  Article 
Target
Name:
Tyrosine-protein kinase Fyn
Synonyms:
FYN | FYN_HUMAN | Proto-oncogene Syn | Proto-oncogene c-Fyn | SLK | SRC | Src-like kinase | p59-Fyn
Type:
Enzyme
Mol. Mass.:
60762.21
Organism:
Homo sapiens (Human)
Description:
P06241
Residue:
537
Sequence:
MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQGLTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL
  
Inhibitor
Name:
BDBM50089570
Synonyms:
CHEMBL3578216
Type:
Small organic molecule
Emp. Form.:
C20H18ClN5O
Mol. Mass.:
379.843
SMILES:
COc1ccc(cc1)-c1nn(CC(Cl)c2ccccc2)c2ncnc(N)c12
Structure:
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