Target
Serine/threonine-protein kinase Chk1
Ligand
BDBM50091288
Substrate
n/a
Meas. Tech.
ChEMBL_1500168 (CHEMBL3584717)
IC50
0.310000±n/a nM
Citation
 Gazzard, LWilliams, KChen, HAxford, LBlackwood, EBurton, BChapman, KCrackett, PDrobnick, JEllwood, CEpler, JFlagella, MGancia, EGill, MGoodacre, SHalladay, JHewitt, JHunt, HKintz, SLyssikatos, JMacleod, CMajor, SMédard, GNarukulla, RRamiscal, JSchmidt, SSeward, EWiesmann, CWu, PYee, SYen, IMalek, S Mitigation of Acetylcholine Esterase Activity in the 1,7-Diazacarbazole Series of Inhibitors of Checkpoint Kinase 1. J Med Chem 58:5053-74 (2015) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase Chk1
Synonyms:
CHEK1 | CHK1 | CHK1 checkpoint homolog | CHK1_HUMAN | Checkpoint kinase-1 (CHK1)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
54443.02
Organism:
Homo sapiens (Human)
Description:
gi_166295192
Residue:
476
Sequence:
MAVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINKMLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLALLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSGFSKHIQSNLDFSPVNSASSEENVKYSSSQPEPRTGLSLWDTSPSYIDKLVQGISFSQPTCPDHMLLNSQLLGTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKLGYQWKKSCMNQVTISTTDRRNNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKIKGKLIDIVSSQKIWLPAT
  
Inhibitor
Name:
BDBM50091288
Synonyms:
CHEMBL3582227
Type:
Small organic molecule
Emp. Form.:
C26H26N6
Mol. Mass.:
422.5248
SMILES:
Cn1cc(cn1)-c1cc2c(cn1)[nH]c1ncc(cc21)-c1ccc(CN2CCCCC2)cc1
Structure:
Search PDB for entries with ligand similarity: