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Target
Prolyl 4-hydroxylase subunit alpha-1
Ligand
BDBM50092609
Substrate
n/a
Meas. Tech.
ChEMBL_1500973 (CHEMBL3587050)
pH
7.8±n/a
Ki
200±n/a nM
Comments
extracted
Citation
 Vasta, JD; Raines, RT Selective inhibition of prolyl 4-hydroxylases by bipyridinedicarboxylates. Bioorg Med Chem 23:3081-90 (2015) [PubMed]  Article 
Target
Name:
Prolyl 4-hydroxylase subunit alpha-1
Synonyms:
4-PH alpha-1 | P4HA | P4HA1 | P4HA1_HUMAN | Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-1 | Prolyl 4-hydroxylase subunit alpha-1
Type:
PROTEIN
Mol. Mass.:
61043.51
Organism:
Homo sapiens (Human)
Description:
ChEMBL_103483
Residue:
534
Sequence:
MIWYILIIGILLPQSLAHPGFFTSIGQMTDLIHTEKDLVTSLKDYIKAEEDKLEQIKKWAEKLDRLTSTATKDPEGFVGHPVNAFKLMKRLNTEWSELENLVLKDMSDGFISNLTIQRQYFPNDEDQVGAAKALLRLQDTYNLDTDTISKGNLPGVKHKSFLTAEDCFELGKVAYTEADYYHTELWMEQALRQLDEGEISTIDKVSVLDYLSYAVYQQGDLDKALLLTKKLLELDPEHQRANGNLKYFEYIMAKEKDVNKSASDDQSDQKTTPKKKGVAVDYLPERQKYEMLCRGEGIKMTPRRQKKLFCRYHDGNRNPKFILAPAKQEDEWDKPRIIRFHDIISDAEIEIVKDLAKPRLRRATISNPITGDLETVHYRISKSAWLSGYENPVVSRINMRIQDLTGLDVSTAEELQVANYGVGGQYEPHFDFARKDEPDAFKELGTGNRIATWLFYMSDVSAGGATVFPEVGASVWPKKGTAVFWYNLFASGEGDYSTRHAACPVLVGNKWVSNKWLHERGQEFRRPCTLSELE
  
Inhibitor
Name:
BDBM50092609
Synonyms:
CHEMBL3586252
Type:
Small organic molecule
Emp. Form.:
C12H8N2O4
Mol. Mass.:
244.2029
SMILES:
OC(=O)c1ccc(nc1)-c1cc(ccn1)C(O)=O
Structure:
Search PDB for entries with ligand similarity: