Target
Mitogen-activated protein kinase 1
Ligand
BDBM50094471
Substrate
n/a
Meas. Tech.
ChEMBL_1503903 (CHEMBL3593136)
IC50
6.7±n/a nM
Citation
 Ward, RAColclough, NChallinor, MDebreczeni, JEEckersley, KFairley, GFeron, LFlemington, VGraham, MAGreenwood, RHopcroft, PHoward, TDJames, MJones, CDJones, CRRenshaw, JRoberts, KSnow, LTonge, MYeung, K Structure-Guided Design of Highly Selective and Potent Covalent Inhibitors of ERK1/2. J Med Chem 58:4790-801 (2015) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 1
Synonyms:
ERK2 | ERT1 | Extracellular signal-regulated kinase 2 | Extracellular signal-regulated kinase 2 (ERK-2) | Extracellular signal-regulated kinase 2 (ERK2) | MAP Kinase 2/ERK2 | MAPK 2 | MAPK1 | MK01_HUMAN | Mitogen activated kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK2) | Mitogen-activated protein kinase 2 | PRKM1 | PRKM2 | p42-MAPK
Type:
Ser/Thr Protein Kinase
Mol. Mass.:
41392.76
Organism:
Homo sapiens (Human)
Description:
P28482
Residue:
360
Sequence:
MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
  
Inhibitor
Name:
BDBM50094471
Synonyms:
CHEMBL3590120
Type:
Small organic molecule
Emp. Form.:
C17H19ClN6O2
Mol. Mass.:
374.825
SMILES:
Clc1cnc(NC2CCOCC2)nc1Nc1ccncc1NC(=O)C=C
Structure:
Search PDB for entries with ligand similarity: