Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetDihydroorotate dehydrogenase
LigandBDBM50300017
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1505693
IC50 9800±n/a nM
Citation Abdullah, IChee, CFLee, YKThunuguntla, SSSatish Reddy, KNellore, KAntony, TVerma, JMun, KWOthman, SSubramanya, HRahman, NA Benzimidazole derivatives as potential dual inhibitors for PARP-1 and DHODH. Bioorg Med Chem23:4669-80 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Dihydroorotate dehydrogenase
Name:Dihydroorotate dehydrogenase
Synonyms:DHOdehase | Dihydroorotate dehydrogenase (DHODH) | Dihydroorotate dehydrogenase, mitochondrial | Dihydroorotate oxidase | Dihydroorotate oxidase (DHODH)
Type:Enzyme
Mol. Mass.:42881.33
Organism:Homo sapiens (Human)
Description:Q02127
Residue:395
Sequence:
MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVR
FTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSV
TPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVN
LGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQER
DGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSET
GGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTF
WGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50300017
NameBDBM50300017
Synonyms:2-(biphenyl-4-yl)-1H-benzo[d]imidazole-4-carboxamide | CHEMBL578185
TypeSmall organic molecule
Emp. Form.C20H15N3O
Mol. Mass.313.3526
SMILESNC(=O)c1cccc2[nH]c(nc12)-c1ccc(cc1)-c1ccccc1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a