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Target
Alkaline phosphatase, placental type
Ligand
BDBM50080274
Substrate
n/a
Meas. Tech.
ChEMBL_1506090 (CHEMBL3595956)
Ki
580000±n/a nM
Citation
 Fonseca, EM; Trivella, DB; Scorsato, V; Dias, MP; Bazzo, NL; Mandapati, KR; de Oliveira, FL; Ferreira-Halder, CV; Pilli, RA; Miranda, PC; Aparicio, R Crystal structures of the apo form and a complex of human LMW-PTP with a phosphonic acid provide new evidence of a secondary site potentially related to the anchorage of natural substrates. Bioorg Med Chem 23:4462-71 (2015) [PubMed]  Article 
Target
Name:
Alkaline phosphatase, placental type
Synonyms:
ALPP | Alkaline phosphatase placental type | PLAP | PPB1_HUMAN
Type:
PROTEIN
Mol. Mass.:
57950.65
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1506090
Residue:
535
Sequence:
MLGPCMLLLLLLLGLRLQLSLGIIPVEEENPDFWNREAAEALGAAKKLQPAQTAAKNLIIFLGDGMGVSTVTAARILKGQKKDKLGPEIPLAMDRFPYVALSKTYNVDKHVPDSGATATAYLCGVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVILGGGRKYMFRMGTPDPEYPDDYSQGGTRLDGKNLVQEWLAKRQGARYVWNRTELMQASLDPSVTHLMGLFEPGDMKYEIHRDSTLDPSLMEMTEAALRLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAIERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPGYVLKDGARPDVTESESGSPEYRQQSAVPLDEETHAGEDVAVFARGPQAHLVHGVQEQTFIAHVMAFAACLEPYTACDLAPPAGTTDAAHPGRSVVPALLPLLAGTLLLLETATAP
  
Inhibitor
Name:
BDBM50080274
Synonyms:
Benzyl-phosphonic acid | CHEMBL299737 | Phenyl-methanephosphonic acid anion | benzylphosphonic acid
Type:
Small organic molecule
Emp. Form.:
C7H9O3P
Mol. Mass.:
172.1183
SMILES:
OP(O)(=O)Cc1ccccc1
Structure:
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