Target
Tyrosine-protein kinase CSK
Ligand
BDBM50096279
Substrate
n/a
Meas. Tech.
ChEMBL_1495634 (CHEMBL3578505)
IC50
290±n/a nM
Citation
 Henry, JRKaufman, MDPeng, SBAhn, YMCaldwell, TMVogeti, LTelikepalli, HLu, WPHood, MMRutkoski, TJSmith, BDVogeti, SMiller, DWise, SCChun, LZhang, XZhang, YKays, LHipskind, PAWrobleski, ADLobb, KLClay, JMCohen, JDWalgren, JLMcCann, DPatel, PClawson, DKGuo, SManglicmot, DGroshong, CLogan, CStarling, JJFlynn, DL Discovery of 1-(3,3-dimethylbutyl)-3-(2-fluoro-4-methyl-5-(7-methyl-2-(methylamino)pyrido[2,3-d]pyrimidin-6-yl)phenyl)urea (LY3009120) as a pan-RAF inhibitor with minimal paradoxical activation and activity against BRAF or RAS mutant tumor cells. J Med Chem 58:4165-79 (2015) [PubMed]  Article 
Target
Name:
Tyrosine-protein kinase CSK
Synonyms:
C-SRC kinase | C-src tyrosine kinase | CSK | CSK_HUMAN | Protein-tyrosine kinase CYL | Tyrosine Kinase CSK
Type:
Tyrosine-protein kinase
Mol. Mass.:
50707.30
Organism:
Homo sapiens (Human)
Description:
P41240
Residue:
450
Sequence:
MSAIQAAWPSGTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGVKAGTKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCDGKVEHYRIMYHASKLSIDEEVYFENLMQLVEHYTSDADGLCTRLIKPKVMEGTVAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNCWHLDAAMRPSFLQLREQLEHIKTHELHL
  
Inhibitor
Name:
BDBM50096279
Synonyms:
CHEMBL3577124
Type:
Small organic molecule
Emp. Form.:
C23H29FN6O
Mol. Mass.:
424.5144
SMILES:
CNc1ncc2cc(c(C)nc2n1)-c1cc(NC(=O)NCCC(C)(C)C)c(F)cc1C
Structure:
Search PDB for entries with ligand similarity: