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TargetProteasome subunit beta type-9
LigandBDBM50099949
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1446800
IC50 34±n/a nM
Citation de Bruin, GHuber, EMXin, BTvan Rooden, EJAl-Ayed, KKim, KBKisselev, AFDriessen, Cvan der Stelt, Mvan der Marel, GAGroll, MOverkleeft, HS Structure-based design of฿1i or฿5i specific inhibitors of human immunoproteasomes. J Med Chem57:6197-209 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Proteasome subunit beta type-9
Name:Proteasome subunit beta type-9
Synonyms:LMP2 | Low molecular mass protein 2 | Macropain chain 7 | Multicatalytic endopeptidase complex chain 7 | PSMB6i | PSMB9 | Proteasome chain 7 | Proteasome subunit beta-1i | RING12 | Really interesting new gene 12 protein
Type:PROTEIN
Mol. Mass.:23256.49
Organism:Homo sapiens (Human)
Description:ChEMBL_106197
Residue:219
Sequence:
MLRAGAPTGDLPRAGEVHTGTTIMAVEFDGGVVMGSDSRVSAGEAVVNRVFDKLSPLHER
IYCALSGSAADAQAVADMAAYQLELHGIELEEPPLVLAAANVVRNISYKYREDLSAHLMV
AGWDQREGGQVYGTLGGMLTRQPFAIGGSGSTFIYGYVDAAYKPGMSPEECRRFTTDAIA
LAMSRDGSSGGVIYLVTITAAGVDHRVILGNELPKFYDE
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50099949
NameBDBM50099949
Synonyms:CHEMBL3319600
TypeSmall organic molecule
Emp. Form.C25H39F2N7O6
Mol. Mass.571.6173
SMILESCCCC[C@H](NC(=O)[C@@H]1CC(F)(F)CN1C(=O)[C@H](C)NC(=O)CN=[N+]=[N-])C(=O)N[C@@H](CC(C)C)C(=O)[C@@]1(C)CO1 |r|
Structure
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