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TargetHistone chaperone ASF1A
LigandBDBM50101708
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1462421
IC50 45000±n/a nM
Citation Miknis, GFStevens, SJSmith, LEOstrov, DAChurchill, ME Development of novel Asf1-H3/H4 inhibitors. Bioorg Med Chem Lett25:963-8 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Histone chaperone ASF1A
Name:Histone chaperone ASF1A
Synonyms:ASF1A | Anti-silencing function protein 1 homolog A | CCG1-interacting factor A | CIA | HSPC146 | Histone chaperone ASF1A | hAsf1 | hAsf1a | hCIA
Type:PROTEIN
Mol. Mass.:22950.75
Organism:Homo sapiens
Description:ChEMBL_109562
Residue:204
Sequence:
MAKVQVNNVVVLDNPSPFYNPFQFEITFECIEDLSEDLEWKIIYVGSAESEEYDQVLDSV
LVGPVPAGRHMFVFQADAPNPGLIPDADAVGVTVVLITCTYRGQEFIRVGYYVNNEYTET
ELRENPPVKPDFSKLQRNILASNPRVTRFHINWEDNTEKLEDAESSNPNLQSLLSTDALP
SASKGWSTSENSLNVMLESHMDCM
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  Blast E-value cutoff:
BDBM50101708
NameBDBM50101708
Synonyms:CHEMBL3394903
TypeSmall organic molecule
Emp. Form.C23H20BrN3O5
Mol. Mass.498.326
SMILESCOc1ccc(cc1)C(=O)Nc1ccc(cc1)C(=O)N\N=C\c1cc(Br)c(O)c(OC)c1
Structure
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