Reaction Details Report a problem with these data
Target
Bacterial leucyl aminopeptidase
Ligand
BDBM50105576
Substrate
n/a
Meas. Tech.
ChEMBL_1507540 (CHEMBL3599796)
Ki
35000±n/a nM
Citation
 Revelant, G; Al-Lakkis-Wehbe, M; Schmitt, M; Alavi, S; Schmitt, C; Roux, L; Al-Masri, M; Schifano-Faux, N; Maiereanu, C; Tarnus, C; Albrecht, S Exploring S1 plasticity and probing S1' subsite of mammalian aminopeptidase N/CD13 with highly potent and selective aminobenzosuberone inhibitors. Bioorg Med Chem 23:3192-207 (2015) [PubMed]  Article 
Target
Name:
Bacterial leucyl aminopeptidase
Synonyms:
AMPX_VIBPR | Bacterial leucyl aminopeptidase precursor
Type:
PROTEIN
Mol. Mass.:
54213.72
Organism:
Vibrio proteolyticus
Description:
ChEMBL_1507540
Residue:
504
Sequence:
MKYTKTLLAMVLSATFCQAYAEDKVWISIGADANQTVMKSGAESILPNSVASSGQVWVGQVDVAQLAELSHNMHEEHNRCGGYMVHPSAQSAMAASAMPTTLASFVMPPITQQATVTAWLPQVDASQITGTISSLESFTNRFYTTTSGAQASDWIASEWQALSASLPNASVKQVSHSGYNQKSVVMTITGSEAPDEWIVIGGHLDSTIGSHTNEQSVAPGADDDASGIAAVTEVIRVLSENNFQPKRSIAFMAYAAEEVGLRGSQDLANQYKSEGKNVVSALQLDMTNYKGSAQDVVFITDYTDSNFTQYLTQLMDEYLPSLTYGFDTCGYACSDHASWHNAGYPAAMPFESKFNDYNPRIHTTQDTLANSDPTGSHAKKFTQLGLAYAIEMGSATGDTPTPGNQLEDGVPVTDLSGSRGSNVWYTFELETQKNLQITTSGGYGDLDLYVKFGSKASKQNWDCRPYLSGNNEVCTFNNASPGTYSVMLTGYSNYSGASLKASTF
  
Inhibitor
Name:
BDBM50105576
Synonyms:
CHEMBL3597445
Type:
Small organic molecule
Emp. Form.:
C18H17ClN2O
Mol. Mass.:
312.793
SMILES:
Cl.NC1CCc2cccc(-c3ccc(cc3)C#N)c2CC1=O
Structure:
Search PDB for entries with ligand similarity: