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Target
Nuclear receptor ROR-beta
Ligand
BDBM50105919
Substrate
n/a
Meas. Tech.
ChEMBL_1506791 (CHEMBL3598950)
EC50
1930±n/a nM
Citation
 Chao, J; Enyedy, I; Van Vloten, K; Marcotte, D; Guertin, K; Hutchings, R; Powell, N; Jones, H; Bohnert, T; Peng, CC; Silvian, L; Hong, VS; Little, K; Banerjee, D; Peng, L; Taveras, A; Viney, JL; Fontenot, J Discovery of biaryl carboxylamides as potent ROR¿ inverse agonists. Bioorg Med Chem Lett 25:2991-7 (2015) [PubMed]  Article 
Target
Name:
Nuclear receptor ROR-beta
Synonyms:
NR1F2 | Nuclear receptor RZR-beta | Nuclear receptor subfamily 1 group F member 2 | RORB | RORB_HUMAN | RZRB | Retinoid-related orphan receptor-beta
Type:
PROTEIN
Mol. Mass.:
53227.30
Organism:
Homo sapiens (Human)
Description:
ChEMBL_107979
Residue:
470
Sequence:
MCENQLKTKADATAQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQNNASYSCPRQRNCLIDRTNRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLYAEVQKHQQRLQEQRQQQSGEAEALARVYSSSISNGLSNLNNETSGTYANGHVIDLPKSEGYYNVDSGQPSPDQSGLDMTGIKQIKQEPIYDLTSVPNLFTYSSFNNGQLAPGITMTEIDRIAQNIIKSHLETCQYTMEELHQLAWQTHTYEEIKAYQSKSREALWQQCAIQITHAIQYVVEFAKRITGFMELCQNDQILLLKSGCLEVVLVRMCRAFNPLNNTVLFEGKYGGMQMFKALGSDDLVNEAFDFAKNLCSLQLTEEEIALFSSAVLISPDRAWLIEPRKVQKLQEKIYFALQHVIQKNHLDDETLAKLIAKIPTITAVCNLHGEKLQVFKQSHPEIVNTLFPPLYKELFNPDCATGCK
  
Inhibitor
Name:
BDBM50105919
Synonyms:
CHEMBL3596632
Type:
Small organic molecule
Emp. Form.:
C23H16Cl2F4N2O3
Mol. Mass.:
518.303
SMILES:
[2H]C([2H])([2H])N(C(=O)c1c(F)cccc1Cl)c1ccc(cc1OCC(F)(F)F)-c1cc(ccc1Cl)C(N)=O
Structure:
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