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TargetPeroxisome proliferator-activated receptor alpha (PPAR alpha)
LigandBDBM50109262
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1508903
EC50>1.000000±n/a nM
Citation Fresno, NMacías-González, MTorres-Zaguirre, ARomero-Cuevas, MSanz-Camacho, PElguero, JPavón, FJRodríguez de Fonseca, FGoya, PPérez-Fernández, R Novel Oxazolidinone-Based Peroxisome Proliferator Activated Receptor Agonists: Molecular Modeling, Synthesis, and Biological Evaluation. J Med Chem58:6639-52 (2015) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Peroxisome proliferator-activated receptor alpha (PPAR alpha)
Name:Peroxisome proliferator-activated receptor alpha (PPAR alpha)
Synonyms:Nuclear receptor subfamily 1 group C member 1 | PPAR alpha/gamma | PPAR-alpha | Peroxisome Proliferator-Activated Receptor alpha | Peroxisome proliferator-activated receptor
Type:Enzyme
Mol. Mass.:52222.08
Organism:Homo sapiens (Human)
Description:Q07869
Residue:468
Sequence:
MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSC
PGSDGSVITDTLSPASSPSSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACE
GCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSE
KAKLKAEILTCEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFV
IHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANL
DLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFD
FAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDI
FLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY
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  Blast E-value cutoff:
BDBM50109262
NameBDBM50109262
Synonyms:CHEMBL3601088
TypeSmall organic molecule
Emp. Form.C33H28F3N3O4
Mol. Mass.587.5883
SMILESFC(F)(F)c1ccc(CNC(=O)c2ccc(NC(=O)c3cccc(CN4[C@H](Cc5ccccc5)COC4=O)c3)cc2)cc1 |r|
Structure
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n/a