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Target
Tyrosine-protein kinase TXK
Ligand
BDBM50109532
Substrate
n/a
Meas. Tech.
ChEMBL_1509370 (CHEMBL3603313)
IC50
36±n/a nM
Citation
 Tan, L; Akahane, K; McNally, R; Reyskens, KM; Ficarro, SB; Liu, S; Herter-Sprie, GS; Koyama, S; Pattison, MJ; Labella, K; Johannessen, L; Akbay, EA; Wong, KK; Frank, DA; Marto, JA; Look, TA; Arthur, JS; Eck, MJ; Gray, NS Development of Selective Covalent Janus Kinase 3 Inhibitors. J Med Chem 58:6589-606 (2015) [PubMed]  Article 
Target
Name:
Tyrosine-protein kinase TXK
Synonyms:
PTK4 | Protein-tyrosine kinase 4 | RLK | Resting lymphocyte kinase | TXK | TXK_HUMAN | Tyrosine-protein kinase TXK (TXK)
Type:
Protein
Mol. Mass.:
61268.80
Organism:
Homo sapiens (Human)
Description:
P42681
Residue:
527
Sequence:
MILSSYNTIQSVFCCCCCCSVQKRQMRTQISLSTDEELPEKYTQRRRPWLSQLSNKKQSNTGRVQPSKRKPLPPLPPSEVAEEKIQVKALYDFLPREPCNLALRRAEEYLILEKYNPHWWKARDRLGNEGLIPSNYVTENKITNLEIYEWYHRNITRNQAEHLLRQESKEGAFIVRDSRHLGSYTISVFMGARRSTEAAIKHYQIKKNDSGQWYVAERHAFQSIPELIWYHQHNAAGLMTRLRYPVGLMGSCLPATAGFSYEKWEIDPSELAFIKEIGSGQFGVVHLGEWRSHIQVAIKAINEGSMSEEDFIEEAKVMMKLSHSKLVQLYGVCIQRKPLYIVTEFMENGCLLNYLRENKGKLRKEMLLSVCQDICEGMEYLERNGYIHRDLAARNCLVSSTCIVKISDFGMTRYVLDDEYVSSFGAKFPIKWSPPEVFLFNKYSSKSDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAISEGFRLYRPHLAPMSIYEVMYSCWHEKPEGRPTFAELLRAVTEIAETW
  
Inhibitor
Name:
BDBM50109532
Synonyms:
CHEMBL3601223
Type:
Small organic molecule
Emp. Form.:
C26H30ClN7O2
Mol. Mass.:
508.015
SMILES:
COc1cc(ccc1Nc1ncc(Cl)c(NCc2cccc(NC(=O)C=C)c2)n1)N1CCN(C)CC1
Structure:
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