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Target
Ribosomal protein S6 kinase alpha-3
Ligand
BDBM50111379
Substrate
n/a
Meas. Tech.
ChEMBL_1509948 (CHEMBL3607766)
EC50
2500±n/a nM
Citation
 Jain, R; Mathur, M; Lan, J; Costales, A; Atallah, G; Ramurthy, S; Subramanian, S; Setti, L; Feucht, P; Warne, B; Doyle, L; Basham, S; Jefferson, AB; Lindvall, M; Appleton, BA; Shafer, CM Discovery of Potent and Selective RSK Inhibitors as Biological Probes. J Med Chem 58:6766-83 (2015) [PubMed]  Article 
Target
Name:
Ribosomal protein S6 kinase alpha-3
Synonyms:
90 kDa ribosomal protein S6 kinase 3 | KS6A3_MOUSE | MAP kinase-activated protein kinase 1b | MAPK-activated protein kinase 1b | MAPKAP kinase 1b | MAPKAPK-1b | Mapkapk1b | Mapkapk1b | RSK-2 | Ribosomal S6 kinase 2 | Ribosomal protein S6 kinase alpha-3 | Rps6ka-rs1 | Rps6ka3 | Rsk2 | S6K-alpha-3 | p90-RSK 3 | p90RSK3 | pp90RSK2
Type:
PROTEIN
Mol. Mass.:
83697.95
Organism:
Mus musculus
Description:
ChEMBL_108393
Residue:
740
Sequence:
MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEGSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL
  
Inhibitor
Name:
BDBM50111379
Synonyms:
CHEMBL3604883
Type:
Small organic molecule
Emp. Form.:
C26H30F2N4O
Mol. Mass.:
452.5394
SMILES:
CC(C)CNc1cc(-c2ccc(cc2)N2CCN(C)CC2)c(cn1)-c1cc(F)c(O)c(F)c1
Structure:
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