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TargetAmiloride-sensitive sodium channel subunit alpha
LigandBDBM50112172
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1512947
IC50 13±n/a nM
Citation Blass, B Novel Pyrazine Amide Compounds. ACS Med Chem Lett6:729-31 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Amiloride-sensitive sodium channel subunit alpha
Name:Amiloride-sensitive sodium channel subunit alpha
Synonyms:Alpha-ENaC | Alpha-NaCH | Amiloride-sensitive sodium channel subunit alpha | Epithelial Na(+) channel subunit alpha | Nonvoltage-gated sodium channel 1 subunit alpha | SCNEA | Scnn1a
Type:PROTEIN
Mol. Mass.:78903.70
Organism:Mus musculus
Description:ChEMBL_109863
Residue:699
Sequence:
MLDHTRAPELNLDLDLDVSNSPKGSMKGNNFKEQDLCPPLPMQGLGKGDKREEQALGPEP
SEPRQPTEEEEALIEFHRSYRELFQFFCNNTTIHGAIRLVCSKHNRMKTAFWAVLWLCTF
GMMYWQFALLFEEYFSYPVSLNINLNSDKLVFPAVTVCTLNPYRYTEIKEDLEELDRITE
QTLFDLYKYNSSYTRQAGGRRRSTRDLRGALPHPLQRLRTPPPPNPARSARSASSSVRDN
NPQVDRKDWKIGFQLCNQNKSDCFYQTYSSGVDAVREWYRFHYINILSRLPDTSPALEEE
ALGSFIFTCRFNQAPCNQANYSQFHHPMYGNCYTFNNKNNSNLWMSSMPGVNNGLSLTLR
TEQNDFIPLLSTVTGARVMVHGQDEPAFMDDGGFNVRPGVETSISMRKEALDSLGGNYGD
CTENGSDVPVKNLYPSKYTQQVCIHSCFQENMIKKCGCAYIFYPKPKGVEFCDYLKQSSW
GYCYYKLQAAFSLDSLGCFSKCRKPCSVTNYKLSAGYSRWPSVKSQDWIFEMLSLQNNYT
INNKRNGVAKLNIFFKELNYKTNSESPSVTMVSLLSNLGSQWSLWFGSSVLSVVEMAELI
FDLLVITLIMLLHRFRSRYWSPGRGARGAREVASTPASSFPSRFCPHPTSPPPSLPQQGT
TPPLALTAPPPAYATLGPSASPLDSAVPGSSACAPAMAL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50112172
NameBDBM50112172
Synonyms:CHEMBL3608427
TypeSmall organic molecule
Emp. Form.C38H54Cl2N8O7
Mol. Mass.805.791
SMILES[Cl-].Nc1nc(N)c(nc1Cl)C(=O)N[C@H]1CCC[N+](CCCc2ccc(OCC(=O)NCCCO)cc2)(CCCc2ccc(OCC(=O)NCCCO)cc2)C1 |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
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