Reaction Details Report a problem with these data
Target
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase
Ligand
BDBM22113
Substrate
n/a
Meas. Tech.
ChEMBL_1511578 (CHEMBL3607078)
Ki
0.002000±n/a nM
Citation
 Evans, GB; Cameron, SA; Luxenburger, A; Guan, R; Suarez, J; Thomas, K; Schramm, VL; Tyler, PC Tight binding enantiomers of pre-clinical drug candidates. Bioorg Med Chem 23:5326-33 (2015) [PubMed]  Article 
Target
Name:
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase
Synonyms:
5'-methylthioadenosine nucleosidase | ACN002_0164 | APZ14_11155 | AWH59_13765 | BN17_45831 | ERS150876_00075 | IY32_16590 | MTA/SAH nucleosidase | MTAN | S-adenosylhomocysteine nucleosidase | mtn | mtnN | pfs
Type:
PROTEIN
Mol. Mass.:
24362.21
Organism:
Escherichia coli
Description:
ChEMBL_109859
Residue:
232
Sequence:
MKIGIIGAMEEEVTLLRDKIEKRQTISLGGCEIYTGQLNGTEVALLKSGIGKVAAALGATLLLEHCKPDVIINTGSAGGLAPTLKVGDIVVSDEARYHDADVTAFGYEYGQLPGCPAGFKADDKLIAAAEACIAELNLNAVRGLIVSGDAFINGSVGLAKIRHNFPQAIAVEMEATAIAHVCHNFNVPFVVVRAISDVADQQSHLSFDEFLAVAAKQSSLMVESLVQKLAHG
  
Inhibitor
Name:
BDBM22113
Synonyms:
(3R,4S)-1-({4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl}methyl)-4-[(methylsulfanyl)methyl]pyrrolidin-3-ol | (3R,4S)-1-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-[(methylsulfanyl)methyl]pyrrolidin-3-ol | (3R,4S)-1-[(9-Deazaadenin-9-yl)methyl]-3-hydroxy-4-methylthiomethylpyrrolidine, 7 | DADMe-ImmA-Me | MT-DADMe-ImmA
Type:
n/a
Emp. Form.:
C13H19N5OS
Mol. Mass.:
293.388
SMILES:
CSC[C@H]1CN(Cc2c[nH]c3c(N)ncnc23)C[C@@H]1O |r|
Structure:
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