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TargetTubulin beta chain
LigandBDBM50012278
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1516025
IC50 1.1±n/a nM
Citation Roman, BIDe Ryck, TPatronov, ASlavov, SHVanhoecke, BWKatritzky, ARBracke, MEStevens, CV 4-Fluoro-3',4',5'-trimethoxychalcone as a new anti-invasive agent. From discovery to initial validation in an in vivo metastasis model. Eur J Med Chem101:627-39 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Tubulin beta chain
Name:Tubulin beta chain
Synonyms:Beta-tubulin | Tubulin beta chain
Type:PROTEIN
Mol. Mass.:49840.26
Organism:Sus scrofa
Description:ChEMBL_105107
Residue:445
Sequence:
MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEAAGNKYV
PRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVV
RKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVVPSPKVSDTVV
EPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMM
AACDPRHGRYLTVAAVFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRG
LKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS
EYQQYQDATADEQGEFEEEGEEDEA
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50012278
NameBDBM50012278
Synonyms:(2ALPHA,2''BETA,3BETA,4ALPHA,5BETA)-VINCALEUKOBLASTINE | CHEMBL159 | VINBLASTINE | VINBLASTINE SULFATE | cid_5388983
TypeSmall organic molecule
Emp. Form.C46H58N4O9
Mol. Mass.810.9741
SMILESCC[C@]1(O)C[C@@H]2CN(C1)CCc1c([nH]c3ccccc13)[C@@](C2)(C(=O)OC)c1cc2c(cc1OC)N(C)[C@@H]1[C@]22CCN3CC=C[C@](CC)([C@@H]23)[C@@H](OC(C)=O)[C@]1(O)C(=O)OC |r,c:48|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a