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Target
Alpha-ketoglutarate-dependent dioxygenase FTO
Ligand
BDBM50117830
Substrate
n/a
Meas. Tech.
ChEMBL_1515854 (CHEMBL3614717)
Kd
13000±n/a nM
Citation
 He, W; Zhou, B; Liu, W; Zhang, M; Shen, Z; Han, Z; Jiang, Q; Yang, Q; Song, C; Wang, R; Niu, T; Han, S; Zhang, L; Wu, J; Guo, F; Zhao, R; Yu, W; Chai, J; Chang, J Identification of A Novel Small-Molecule Binding Site of the Fat Mass and Obesity Associated Protein (FTO). J Med Chem 58:7341-8 (2015) [PubMed]  Article 
Target
Name:
Alpha-ketoglutarate-dependent dioxygenase FTO
Synonyms:
FTO | FTO_HUMAN | Fat mass and obesity-associated protein | KIAA1752
Type:
PROTEIN
Mol. Mass.:
58263.75
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1515854
Residue:
505
Sequence:
MKRTPTAEEREREAKKLRLLEELEDTWLPYLTPKDDEFYQQWQLKYPKLILREASSVSEELHKEVQEAFLTLHKHGCLFRDLVRIQGKDLLTPVSRILIGNPGCTYKYLNTRLFTVPWPVKGSNIKHTEAEIAAACETFLKLNDYLQIETIQALEELAAKEKANEDAVPLCMSADFPRVGMGSSYNGQDEVDIKSRAAYNVTLLNFMDPQKMPYLKEEPYFGMGKMAVSWHHDENLVDRSAVAVYSYSCEGPEEESEDDSHLEGRDPDIWHVGFKISWDIETPGLAIPLHQGDCYFMLDDLNATHQHCVLAGSQPRFSSTHRVAECSTGTLDYILQRCQLALQNVCDDVDNDDVSLKSFEPAVLKQGEEIHNEVEFEWLRQFWFQGNRYRKCTDWWCQPMAQLEALWKKMEGVTNAVLHEVKREGLPVEQRNEILTAILASLTARQNLRREWHARCQSRIARTLPADQKPECRPYWEKDDASMPLPFDLTDIVSELRGQLLEAKP
  
Inhibitor
Name:
BDBM50117830
Synonyms:
CHEMBL3613953
Type:
Small organic molecule
Emp. Form.:
C17H16ClNO3
Mol. Mass.:
317.767
SMILES:
Oc1cc(O)c(NC(=O)C2(CCC2)c2ccccc2)cc1Cl
Structure:
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