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TargetMuscarinic acetylcholine receptor M2
LigandBDBM50038210
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1517984
EC50 296±n/a nM
Citation Liu, BCroy, CHHitchcock, SAAllen, JRRao, ZEvans, DBures, MGMcKinzie, DLWatt, MLStuart Gregory, GHansen, MMHoogestraat, PJJamison, JAOkha-Mokube, FMStratford, RETurner, WBymaster, FFelder, CC Design and synthesis of N-[6-(Substituted Aminoethylideneamino)-2-Hydroxyindan-1-yl]arylamides as selective and potent muscarinic M1 agonists. Bioorg Med Chem Lett25:4158-63 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Muscarinic acetylcholine receptor M2
Name:Muscarinic acetylcholine receptor M2 and M5
Synonyms:CHRM2 | Cholinergic, muscarinic M2 | RecName: Full=Muscarinic acetylcholine receptor M2
Type:GPCR
Mol. Mass.:51730.61
Organism:Homo sapiens (Human)
Description:P08172
Residue:466
Sequence:
MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNY
FLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFD
RYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQF
FSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRI
VKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDE
ITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNI
VARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNT
VWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50038210
NameBDBM50038210
Synonyms:5-(2-Ethyl-2H-tetrazol-5-yl)-1-methyl-1,2,3,6-tetrahydro-pyridine | Alvameline | CHEMBL131428
TypeSmall organic molecule
Emp. Form.C9H15N5
Mol. Mass.193.2489
SMILESCCn1nnc(n1)C1=CCCN(C)C1 |t:8|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a