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Target
Tyrosine-protein kinase SYK
Ligand
BDBM50123573
Substrate
n/a
Meas. Tech.
ChEMBL_1521566 (CHEMBL3627444)
IC50
16±n/a nM
Citation
 Thoma, G; Veenstra, S; Strang, R; Blanz, J; Vangrevelinghe, E; Berghausen, J; Lee, CC; Zerwes, HG Orally bioavailable Syk inhibitors with activity in a rat PK/PD model. Bioorg Med Chem Lett 25:4642-7 (2015) [PubMed]  Article 
Target
Name:
Tyrosine-protein kinase SYK
Synonyms:
KSYK_HUMAN | SYK | Spleen Tyrosine Kinase | Spleen tyrosine kinase (SYK) | Tyrosine-protein kinase SYK (Syk)
Type:
Enzyme
Mol. Mass.:
72079.99
Organism:
Homo sapiens (Human)
Description:
P43405
Residue:
635
Sequence:
MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPFEDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPKPGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN
  
Inhibitor
Name:
BDBM50123573
Synonyms:
CHEMBL3622697
Type:
Small organic molecule
Emp. Form.:
C16H14F2N4O3S
Mol. Mass.:
380.369
SMILES:
[H][C@@]1(CNC(=O)O1)[C@@H](C)Oc1cc(cc2nscc12)-c1cnn(c1)C(F)F |r|
Structure:
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