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TargetAcid-sensing ion channel 5
LigandBDBM17636
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1520854
EC50 2600000±n/a nM
Citation Hendriks, CMPenning, TMZang, TWiemuth, DGründer, SSanhueza, IASchoenebeck, FBolm, C Pentafluorosulfanyl-containing flufenamic acid analogs: Syntheses, properties and biological activities. Bioorg Med Chem Lett25:4437-40 (2015) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Acid-sensing ion channel 5
Name:Acid-sensing ion channel 5
Synonyms:ASIC5 | Accn5 | Acid-sensing ion channel 5 | Amiloride-sensitive cation channel 5 | Asic5 | BLINaC | Blinac | Brain-liver-intestine amiloride-sensitive Na(+) channel
Type:PROTEIN
Mol. Mass.:56474.87
Organism:Rattus norvegicus
Description:ChEMBL_109894
Residue:495
Sequence:
MEHTEKSKGPAEKGLLGKIRRYLSKRPLPSPTDRKKFDHDFAISTSFHGIHNIAQNQNKV
RKVIWLSVVLGSVSLLVWQIYSRLVNYFMWPTTTSIEVQYVEKIEFPAVTFCNLNRFQTE
AVSRFGIIFFLWDIVSKVLRLQEISGNNTGSPEALDFVASHRNFSITEFVKNNGFYLNHD
TLVHCEFFGKTCDPKDFKHVFTEYGNCFTFNYGENVQSKNKVSVSGRGLKLLLDVHQEEF
TDNPVPGFADAGVIFVIHSPKKEPQFDGLGLSSPVGMHARVTIRQLKTIHQEYPWGECNP
DIKLRNFTTYSTYGCLKECKAKHIQRLCGCLPFLLPGNGVECDLLKYYNCVSPILDHIER
KGLCTMGTHNSSCPVPCEETEYPATIAYSTFPSQRATKFLAKKLNQSQEYIRENLVNIEI
NYSDLNYKITQQQKAVSVPELLADVGGQLGLFCGASLITIIEIIEYLFTSFYWVFIFFLL
KILEMIQRTSPPQTV
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  Blast E-value cutoff:
BDBM17636
NameBDBM17636
Synonyms:2-{[3-(trifluoromethyl)phenyl]amino}benzoic acid | Arlef | CHEMBL23588 | Flufenamic acid | Nichisedan | US9271961, Flufenamic Acid
TypeSmall organic molecule
Emp. Form.C14H10F3NO2
Mol. Mass.281.2299
SMILESOC(=O)c1ccccc1Nc1cccc(c1)C(F)(F)F
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a