Target
Folate receptor alpha
Ligand
BDBM50126173
Substrate
n/a
Meas. Tech.
ChEMBL_1523802 (CHEMBL3632253)
IC50
>1000±n/a nM
Citation
 Wang, LWallace, ARaghavan, SDeis, SMWilson, MRYang, SPolin, LWhite, KKushner, JOrr, SGeorge, CO'Connor, CHou, ZMitchell-Ryan, SDann, CEMatherly, LHGangjee, A 6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Regioisomers as Targeted Antifolates for Folate Receptora and the Proton-Coupled Folate Transporter in Human Tumors. J Med Chem 58:6938-59 (2015) [PubMed]  Article 
Target
Name:
Folate receptor alpha
Synonyms:
Adult folate-binding protein | FBP | FOLR | FOLR1 | FOLR1_HUMAN | FR-alpha | Folate receptor 1 | Folate receptor, adult | KB cells FBP | Ovarian tumor-associated antigen MOv18
Type:
PROTEIN
Mol. Mass.:
29827.41
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1469596
Residue:
257
Sequence:
MAQRMTTQLLLLLVWVAVVGEAQTRIAWARTELLNVCMNAKHHKEKPGPEDKLHEQCRPWRKNACCSTNTSQEAHKDVSYLYRFNWNHCGEMAPACKRHFIQDTCLYECSPNLGPWIQQVDQSWRKERVLNVPLCKEDCEQWWEDCRTSYTCKSNWHKGWNWTSGFNKCAVGAACQPFHFYFPTPTVLCNEIWTHSYKVSNYSRGSGRCIQMWFDPAQGNPNEEVARFYAAAMSGAGPWAAWPFLLSLALMLLWLLS
  
Inhibitor
Name:
BDBM50126173
Synonyms:
CHEMBL3628345
Type:
Small organic molecule
Emp. Form.:
C19H21N5O6S
Mol. Mass.:
447.465
SMILES:
Nc1nc(N)c2c(CCCc3csc(c3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)coc2n1 |r|
Structure:
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