Reaction Details Report a problem with these data
Target
Mu-type opioid receptor
Ligand
BDBM50127700
Substrate
n/a
Meas. Tech.
ChEMBL_1522819 (CHEMBL3630378)
EC50
0.062900±n/a nM
Citation
 Liu, X; Zhao, L; Wang, Y; Mou, L; Yang, J; Zhang, Y; Wang, D; Wang, R Design, synthesis, and evaluation of new endomorphin analogs with enhanced central antinociception after peripheral administration. Bioorg Med Chem Lett 25:5393-7 (2015) [PubMed]  Article 
Target
Name:
Mu-type opioid receptor
Synonyms:
M-OR-1 | MOP | MOR-1 | MOR1 | MUOR1 | Mu Opioid Receptor | Mu opiate receptor | OPIATE Mu | OPRM1 | OPRM_HUMAN | hMOP | mu-type opioid receptor isoform MOR-1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44789.51
Organism:
Homo sapiens (Human)
Description:
P35372
Residue:
400
Sequence:
MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM50127700
Synonyms:
CHEMBL3629337
Type:
Small organic molecule
Emp. Form.:
C33H36N6O5S
Mol. Mass.:
628.741
SMILES:
N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C(=C)C(N)=O)c1cccs1 |r|
Structure:
Search PDB for entries with ligand similarity: