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Target
Carbonic anhydrase 14
Ligand
BDBM50133391
Substrate
n/a
Meas. Tech.
ChEMBL_1525822 (CHEMBL3635736)
Ki
0.750000±n/a nM
Citation
 La Regina, G; Coluccia, A; Famiglini, V; Pelliccia, S; Monti, L; Vullo, D; Nuti, E; Alterio, V; De Simone, G; Monti, SM; Pan, P; Parkkila, S; Supuran, CT; Rossello, A; Silvestri, R Discovery of 1,1'-Biphenyl-4-sulfonamides as a New Class of Potent and Selective Carbonic Anhydrase XIV Inhibitors. J Med Chem 58:8564-72 (2015) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 14
Synonyms:
CA-XIV | CA14 | CAH14_HUMAN | Carbonate dehydratase XIV | Carbonic Anhydrase XIV | Carbonic anhydrase | Carbonic anhydrase 14 | Carbonic anhydrase 14 (CA XIV) | Carbonic anhydrase XIV (CA XIV)
Type:
Enzyme
Mol. Mass.:
37665.67
Organism:
Homo sapiens (Human)
Description:
Human (cloned) isozyme.
Residue:
337
Sequence:
MLFSALLLEVIWILAADGGQHWTYEGPHGQDHWPASYPECGNNAQSPIDIQTDSVTFDPDLPALQPHGYDQPGTEPLDLHNNGHTVQLSLPSTLYLGGLPRKYVAAQLHLHWGQKGSPGGSEHQINSEATFAELHIVHYDSDSYDSLSEAAERPQGLAVLGILIEVGETKNIAYEHILSHLHEVRHKDQKTSVPPFNLRELLPKQLGQYFRYNGSLTTPPCYQSVLWTVFYRRSQISMEQLEKLQGTLFSTEEEPSKLLVQNYRALQPLNQRMVFASFIQAGSSYTTGEMLSLGVGILVGCLCLLLAVYFIARKIRKKRLENRKSVVFTSAQATTEA
  
Inhibitor
Name:
BDBM50133391
Synonyms:
CHEMBL3632827
Type:
Small organic molecule
Emp. Form.:
C13H11NO4S
Mol. Mass.:
277.296
SMILES:
NS(=O)(=O)c1ccc(cc1)-c1ccc(cc1)C(O)=O
Structure:
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