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TargetCarbonic Anhydrase XIV
LigandBDBM50133394
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1525822
Ki 0.410000±n/a nM
Citation La Regina, GColuccia, AFamiglini, VPelliccia, SMonti, LVullo, DNuti, EAlterio, VDe Simone, GMonti, SMPan, PParkkila, SSupuran, CTRossello, ASilvestri, R Discovery of 1,1'-Biphenyl-4-sulfonamides as a New Class of Potent and Selective Carbonic Anhydrase XIV Inhibitors. J Med Chem58:8564-72 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Carbonic Anhydrase XIV
Name:Carbonic Anhydrase XIV
Synonyms:CA-XIV | Carbonate dehydratase XIV | Carbonic anhydrase 14 | Carbonic anhydrase 14 (CA XIV) | Carbonic anhydrase XIV (CA XIV)
Type:Enzyme
Mol. Mass.:37665.67
Organism:Homo sapiens (Human)
Description:Human (cloned) isozyme.
Residue:337
Sequence:
MLFSALLLEVIWILAADGGQHWTYEGPHGQDHWPASYPECGNNAQSPIDIQTDSVTFDPD
LPALQPHGYDQPGTEPLDLHNNGHTVQLSLPSTLYLGGLPRKYVAAQLHLHWGQKGSPGG
SEHQINSEATFAELHIVHYDSDSYDSLSEAAERPQGLAVLGILIEVGETKNIAYEHILSH
LHEVRHKDQKTSVPPFNLRELLPKQLGQYFRYNGSLTTPPCYQSVLWTVFYRRSQISMEQ
LEKLQGTLFSTEEEPSKLLVQNYRALQPLNQRMVFASFIQAGSSYTTGEMLSLGVGILVG
CLCLLLAVYFIARKIRKKRLENRKSVVFTSAQATTEA
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50133394
NameBDBM50133394
Synonyms:CHEMBL3632830
TypeSmall organic molecule
Emp. Form.C12H10N2O4S
Mol. Mass.278.284
SMILESNS(=O)(=O)c1ccc(cc1)-c1ccc(cc1)[N+]([O-])=O
Structure
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n/a