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Target
DNA gyrase subunit B
Ligand
BDBM50134212
Substrate
n/a
Meas. Tech.
ChEBML_1542254
IC50
<8.0±n/a nM
Citation
 Zhang, J; Yang, Q; Romero, JA; Cross, J; Wang, B; Poutsiaka, KM; Epie, F; Bevan, D; Wu, Y; Moy, T; Daniel, A; Chamberlain, B; Carter, N; Shotwell, J; Arya, A; Kumar, V; Silverman, J; Nguyen, K; Metcalf, CA; Ryan, D; Lippa, B; Dolle, RE Discovery of Indazole Derivatives as a Novel Class of Bacterial Gyrase B Inhibitors. ACS Med Chem Lett 6:1080-5 (2015) [PubMed]  Article 
Target
Name:
DNA gyrase subunit B
Synonyms:
DNA gyrase | DNA gyrase subunit B (DNA gyraseB) | DNA gyrase subunit B (gyrB) | GYRB_STAAU | gyrB
Type:
Enzyme Subunit
Mol. Mass.:
72530.91
Organism:
Staphylococcus aureus
Description:
n/a
Residue:
644
Sequence:
MVTALSDVNNTDNYGAGQIQVLEGLEAVRKRPGMYIGSTSERGLHHLVWEIVDNSIDEALAGYANQIEVVIEKDNWIKVTDNGRGIPVDIQEKMGRPAVEVILTVLHAGGKFGGGGYKVSGGLHGVGSSVVNALSQDLEVYVHRNETIYHQAYKKGVPQFDLKEVGTTDKTGTVIRFKADGEIFTETTVYNYETLQQRIRELAFLNKGIQITLRDERDEENVREDSYHYEGGIKSYVELLNENKEPIHDEPIYIHQSKDDIEVEIAIQYNSGYATNLLTYANNIHTYEGGTHEDGFKRALTRVLNSYGLSSKIMKEEKDRLSGEDTREGMTAIISIKHGDPQFEGQTKTKLGNSEVRQVVDKLFSEHFERFLYENPQVARTVVEKGIMAARARVAAKKAREVTRRKSALDVASLPGKLADCSSKSPEECEIFLVEGDSAGGSTKSGRDSRTQAILPLRGKILNVEKARLDRILNNNEIRQMITAFGTGIGGDFDLAKARYHKIVIMTDADVDGAHIRTLLLTFFYRFMRPLIEAGYVYIAQPPLYKLTQGKQKYYVYNDRELDKLKSELNPTPKWSIARYKGLGEMNADQLWETTMNPEHRALLQVKLEDAIEADQTFEMLMGDVVENRRQFIEDNAVYANLDF
  
Inhibitor
Name:
BDBM50134212
Synonyms:
CHEMBL3741453
Type:
Small organic molecule
Emp. Form.:
C18H15N5O3S
Mol. Mass.:
381.408
SMILES:
CCCn1c2[nH]nc(-c3cnc(s3)-c3ccc(nc3)C(O)=O)c2ccc1=O
Structure:
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