Target
Muscarinic acetylcholine receptor M1
Ligand
BDBM50135217
Substrate
n/a
Meas. Tech.
ChEMBL_1545717 (CHEMBL3748814)
EC50
9.0±n/a nM
Citation
 Davoren, JEO'Neil, SVAnderson, DPBrodney, MAChenard, LDlugolenski, KEdgerton, JRGreen, MGarnsey, MGrimwood, SHarris, ARKauffman, GWLaChapelle, ELazzaro, JTLee, CWLotarski, SMNason, DMObach, RSReinhart, VSalomon-Ferrer, RSteyn, SJWebb, DYan, JZhang, L Design and optimization of selective azaindole amide M1 positive allosteric modulators. Bioorg Med Chem Lett 26:650-5 (2016) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M1
Synonyms:
ACM1_HUMAN | CHRM1 | Cholinergic receptor, muscarinic 1 | Cholinergic, muscarinic M1
Type:
Protein
Mol. Mass.:
51442.54
Organism:
Homo sapiens (Human)
Description:
P11229
Residue:
460
Sequence:
MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
  
Inhibitor
Name:
BDBM50135217
Synonyms:
CHEMBL3746869
Type:
Small organic molecule
Emp. Form.:
C25H27N5O3
Mol. Mass.:
445.5136
SMILES:
Cc1ccnc2c(cn(Cc3ccc(cc3)-c3ccn(C)n3)c12)C(=O)N[C@H]1CCOC[C@@H]1O |r|
Structure:
Search PDB for entries with ligand similarity: