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Target
Sphingosine 1-phosphate receptor 5
Ligand
BDBM50136551
Substrate
n/a
Meas. Tech.
ChEMBL_1548097 (CHEMBL3757929)
EC50
350±n/a nM
Citation
 Horan, JC; Kuzmich, D; Liu, P; DiSalvo, D; Lord, J; Mao, C; Hopkins, TD; Yu, H; Harcken, C; Betageri, R; Hill-Drzewi, M; Patenaude, L; Patel, M; Fletcher, K; Terenzzio, D; Linehan, B; Xia, H; Patel, M; Studwell, D; Miller, C; Hickey, E; Levin, JI; Smith, D; Kemper, RA; Modis, LK; Bannen, LC; Chan, DS; Mac, MB; Ng, S; Wang, Y; Xu, W; Lemieux, RM Late-stage optimization of a tercyclic class of S1P3-sparing, S1P1 receptor agonists. Bioorg Med Chem Lett 26:466-71 (2016) [PubMed]  Article 
Target
Name:
Sphingosine 1-phosphate receptor 5
Synonyms:
EDG8 | Endothelial differentiation sphingolipid G-protein-coupled receptor 8 | S1P5 | S1PR5 | S1PR5_HUMAN | Sphingosine 1-phosphate receptor | Sphingosine 1-phosphate receptor Edg-8
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
41796.42
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
398
Sequence:
MESGLLRPAPVSEVIVLHYNYTGKLRGARYQPGAGLRADAVVCLAVCAFIVLENLAVLLVLGRHPRFHAPMFLLLGSLTLSDLLAGAAYAANILLSGPLTLKLSPALWFAREGGVFVALTASVLSLLAIALERSLTMARRGPAPVSSRGRTLAMAAAAWGVSLLLGLLPALGWNCLGRLDACSTVLPLYAKAYVLFCVLAFVGILAAICALYARIYCQVRANARRLPARPGTAGTTSTRARRKPRSLALLRTLSVVLLAFVACWGPLFLLLLLDVACPARTCPVLLQADPFLGLAMANSLLNPIIYTLTNRDLRHALLRLVCCGRHSCGRDPSGSQQSASAAEASGGLRRCLPPGLDGSFSGSERSSPQRDGLDTSGSTGSPGAPTAARTLVSEPAAD
  
Inhibitor
Name:
BDBM50136551
Synonyms:
CHEMBL3753609
Type:
Small organic molecule
Emp. Form.:
C22H26N6O3
Mol. Mass.:
422.4802
SMILES:
CC(C)Nc1cc(cc(C)n1)-c1nc(no1)-c1ccc(O[C@H]2CCC(=O)NC2)c(C)n1 |r|
Structure:
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