Target
Sphingosine 1-phosphate receptor 5
Ligand
BDBM50136552
Substrate
n/a
Meas. Tech.
ChEMBL_1548097 (CHEMBL3757929)
EC50
340±n/a nM
Citation
 Horan, JCKuzmich, DLiu, PDiSalvo, DLord, JMao, CHopkins, TDYu, HHarcken, CBetageri, RHill-Drzewi, MPatenaude, LPatel, MFletcher, KTerenzzio, DLinehan, BXia, HPatel, MStudwell, DMiller, CHickey, ELevin, JISmith, DKemper, RAModis, LKBannen, LCChan, DSMac, MBNg, SWang, YXu, WLemieux, RM Late-stage optimization of a tercyclic class of S1P3-sparing, S1P1 receptor agonists. Bioorg Med Chem Lett 26:466-71 (2016) [PubMed]  Article 
Target
Name:
Sphingosine 1-phosphate receptor 5
Synonyms:
EDG8 | Endothelial differentiation sphingolipid G-protein-coupled receptor 8 | S1P5 | S1PR5 | S1PR5_HUMAN | Sphingosine 1-phosphate receptor | Sphingosine 1-phosphate receptor Edg-8
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
41796.42
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
398
Sequence:
MESGLLRPAPVSEVIVLHYNYTGKLRGARYQPGAGLRADAVVCLAVCAFIVLENLAVLLVLGRHPRFHAPMFLLLGSLTLSDLLAGAAYAANILLSGPLTLKLSPALWFAREGGVFVALTASVLSLLAIALERSLTMARRGPAPVSSRGRTLAMAAAAWGVSLLLGLLPALGWNCLGRLDACSTVLPLYAKAYVLFCVLAFVGILAAICALYARIYCQVRANARRLPARPGTAGTTSTRARRKPRSLALLRTLSVVLLAFVACWGPLFLLLLLDVACPARTCPVLLQADPFLGLAMANSLLNPIIYTLTNRDLRHALLRLVCCGRHSCGRDPSGSQQSASAAEASGGLRRCLPPGLDGSFSGSERSSPQRDGLDTSGSTGSPGAPTAARTLVSEPAAD
  
Inhibitor
Name:
BDBM50136552
Synonyms:
CHEMBL3753300
Type:
Small organic molecule
Emp. Form.:
C24H29N5O3
Mol. Mass.:
435.5188
SMILES:
CC(C)Cc1cc(cc(C)n1)-c1nc(no1)-c1cc(C)c(OC[C@@H]2CCC(=O)N2)c(C)n1 |r|
Structure:
Search PDB for entries with ligand similarity: