Target
Casein kinase II subunit alpha'
Ligand
BDBM50144685
Substrate
n/a
Meas. Tech.
ChEMBL_1552124 (CHEMBL3760461)
IC50
12±n/a nM
Citation
 Ohno, HMinamiguchi, DNakamura, SShu, KOkazaki, SHonda, MMisu, RMoriwaki, HNakanishi, SOishi, SKinoshita, TNakanishi, IFujii, N Structure-activity relationship study of 4-(thiazol-5-yl)benzoic acid derivatives as potent protein kinase CK2 inhibitors. Bioorg Med Chem 24:1136-41 (2016) [PubMed]  Article 
Target
Name:
Casein kinase II subunit alpha'
Synonyms:
CK2A2 | CSK22_HUMAN | CSNK2A2 | Casein kinase II alpha (prime) | Casein kinase II alpha' | Casein kinase II subunit alpha (CK2A2) | Casein kinase II subunit alpha (CSNK2A2)
Type:
Protein
Mol. Mass.:
41223.82
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
350
Sequence:
MPGPAAGSRARVYAEVNSLRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFYPVVKEQSQPCADNAVLSSGLTAAR
  
Inhibitor
Name:
BDBM50144685
Synonyms:
CHEMBL3758270
Type:
Small organic molecule
Emp. Form.:
C25H20N2O5S
Mol. Mass.:
460.502
SMILES:
COc1ccc(cc1)C(=O)Nc1ncc(s1)-c1ccc(cc1OCc1ccccc1)C(O)=O
Structure:
Search PDB for entries with ligand similarity: