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Target
Tryptophan 5-hydroxylase 1
Ligand
BDBM50145657
Substrate
n/a
Meas. Tech.
ChEMBL_1556286 (CHEMBL3769285)
IC50
>100000±n/a nM
Citation
 Goldberg, DR; De Lombaert, S; Aiello, R; Bourassa, P; Barucci, N; Zhang, Q; Paralkar, V; Valentine, J; Zavadoski, W Discovery of spirocyclic proline tryptophan hydroxylase-1 inhibitors. Bioorg Med Chem Lett 26:1124-9 (2016) [PubMed]  Article 
Target
Name:
Tryptophan 5-hydroxylase 1
Synonyms:
TPH | TPH1 | TPH1_HUMAN | TPRH | TRPH | Tryptophan 5-monooxygenase 1
Type:
PROTEIN
Mol. Mass.:
50990.64
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1361824
Residue:
444
Sequence:
MIEDNKENKDHSLERGRASLIFSLKNEVGGLIKALKIFQEKHVNLLHIESRKSKRRNSEFEIFVDCDINREQLNDIFHLLKSHTNVLSVNLPDNFTLKEDGMETVPWFPKKISDLDHCANRVLMYGSELDADHPGFKDNVYRKRRKYFADLAMNYKHGDPIPKVEFTEEEIKTWGTVFQELNKLYPTHACREYLKNLPLLSKYCGYREDNIPQLEDVSNFLKERTGFSIRPVAGYLSPRDFLSGLAFRVFHCTQYVRHSSDPFYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGASEEAVQKLATCYFFTVEFGLCKQDGQLRVFGAGLLSSISELKHALSGHAKVKPFDPKITCKQECLITTFQDVYFVSESFEDAKEKMREFTKTIKRPFGVKYNPYTRSIQILKDTKSITSAMNELQHDLDVVSDALAKVSRKPSI
  
Inhibitor
Name:
BDBM50145657
Synonyms:
CHEBI:47069 | CHEMBL412813
Type:
Small organic molecule
Emp. Form.:
C9H10ClNO2
Mol. Mass.:
199.634
SMILES:
N[C@@H](Cc1ccc(Cl)cc1)C(O)=O |r|
Structure:
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