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Target
Tryptophan 5-hydroxylase 1
Ligand
BDBM50145666
Substrate
n/a
Meas. Tech.
ChEMBL_1556269 (CHEMBL3769268)
IC50
6220±n/a nM
Citation
 Goldberg, DR; De Lombaert, S; Aiello, R; Bourassa, P; Barucci, N; Zhang, Q; Paralkar, V; Valentine, J; Zavadoski, W Discovery of spirocyclic proline tryptophan hydroxylase-1 inhibitors. Bioorg Med Chem Lett 26:1124-9 (2016) [PubMed]  Article 
Target
Name:
Tryptophan 5-hydroxylase 1
Synonyms:
TPH | TPH1 | TPH1_HUMAN | TPRH | TRPH | Tryptophan 5-monooxygenase 1
Type:
PROTEIN
Mol. Mass.:
50990.64
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1361824
Residue:
444
Sequence:
MIEDNKENKDHSLERGRASLIFSLKNEVGGLIKALKIFQEKHVNLLHIESRKSKRRNSEFEIFVDCDINREQLNDIFHLLKSHTNVLSVNLPDNFTLKEDGMETVPWFPKKISDLDHCANRVLMYGSELDADHPGFKDNVYRKRRKYFADLAMNYKHGDPIPKVEFTEEEIKTWGTVFQELNKLYPTHACREYLKNLPLLSKYCGYREDNIPQLEDVSNFLKERTGFSIRPVAGYLSPRDFLSGLAFRVFHCTQYVRHSSDPFYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGASEEAVQKLATCYFFTVEFGLCKQDGQLRVFGAGLLSSISELKHALSGHAKVKPFDPKITCKQECLITTFQDVYFVSESFEDAKEKMREFTKTIKRPFGVKYNPYTRSIQILKDTKSITSAMNELQHDLDVVSDALAKVSRKPSI
  
Inhibitor
Name:
BDBM50145666
Synonyms:
CHEMBL3764358
Type:
Small organic molecule
Emp. Form.:
C24H26ClF3N8O3
Mol. Mass.:
566.963
SMILES:
Cc1ccn(n1)-c1cc(Cl)ccc1[C@@H](Oc1cc(nc(N)n1)N1CC2CC(C1)N2C[C@H](N)C(O)=O)C(F)(F)F |r,THB:29:28:22.23.27:25|
Structure:
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