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Target
Inhibitor of nuclear factor kappa-B kinase subunit beta
Ligand
BDBM50146934
Substrate
n/a
Meas. Tech.
ChEMBL_1553193 (CHEMBL3767151)
IC50
4000±n/a nM
Citation
 Kim, D; Kim, YG; Seo, JH; Shin, KJ Identification and characterization of potent, selective and metabolically stable IKKß inhibitor. Bioorg Med Chem Lett 26:1120-3 (2016) [PubMed]  Article 
Target
Name:
Inhibitor of nuclear factor kappa-B kinase subunit beta
Synonyms:
IKKB_MOUSE | Ikbkb | Ikkb
Type:
PROTEIN
Mol. Mass.:
86687.79
Organism:
Mus musculus
Description:
ChEMBL_835035
Residue:
757
Sequence:
MSWSPSLPTQTCGAWEMKERLGTGGFGNVIRWHNQATGEQIAIKQCRQELSPKNRNRWCLEIQIMRRLNHPNVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRRYLNQFENCCGLREGAVLTLLSDIASALRYLHENRIIHRDLKPENIVLQQGEKRLIHKIIDLGYAKELDQGSLCTSFVGTLQYLAPELLEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSEVDIVVSEDLNGAVKFSSSLPFPNNLNSVLAERLEKWLQLMLMWHPRQRGTDPQYGPNGCFRALDDILNLKLVHVLNMVTGTVHTYPVTEDESLQSLKTRIQENTGILETDQELLQKAGLVLLPDKPATQCISDSKTNEGLTLDMDLVFLLDNSKINYETQITPRPPPESVSCILQEPKRNLSFFQLRKVWGQVWHSIQTLKEDCNRLQQGQRAAMMSLLRNNSCLSKMKNAMASTAQQLKAKLDFFKTSIQIDLEKYKEQTEFGITSDKLLLAWREMEQAVEQCGRENDVKHLVERMMALQTDIVDLQRSPMGRKQGGTLDDLEEQARELYRKLREKPRDQRTEGDSQEMVRLLLQAIQSFEKKVRVIYTQLSKTVVCKQKALELLPKVEEVVSLMNEDERTVVRLQEKRQKELWNLLKIACSKVRGPVSGSPDSMNVSRLSHPGQLMSQPSSACDSLPESDKKSEELVAEAHALCSRLESALQDTVKEQDRSFTTLDWSWLQMEDEERCSLEQACD
  
Inhibitor
Name:
BDBM50146934
Synonyms:
CHEMBL3765189
Type:
Small organic molecule
Emp. Form.:
C31H33N3O4S2
Mol. Mass.:
575.741
SMILES:
COc1ccc(Oc2ccc(\C=C3/SC(=S)N(C3=O)c3ccc(OCCCN4CCN(C)CC4)cc3)cc2)cc1
Structure:
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