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Target
Inhibitor of nuclear factor kappa-B kinase subunit beta
Ligand
BDBM50146943
Substrate
n/a
Meas. Tech.
ChEMBL_1553193 (CHEMBL3767151)
IC50
8000±n/a nM
Citation
 Kim, D; Kim, YG; Seo, JH; Shin, KJ Identification and characterization of potent, selective and metabolically stable IKKß inhibitor. Bioorg Med Chem Lett 26:1120-3 (2016) [PubMed]  Article 
Target
Name:
Inhibitor of nuclear factor kappa-B kinase subunit beta
Synonyms:
IKKB_MOUSE | Ikbkb | Ikkb
Type:
PROTEIN
Mol. Mass.:
86687.79
Organism:
Mus musculus
Description:
ChEMBL_835035
Residue:
757
Sequence:
MSWSPSLPTQTCGAWEMKERLGTGGFGNVIRWHNQATGEQIAIKQCRQELSPKNRNRWCLEIQIMRRLNHPNVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRRYLNQFENCCGLREGAVLTLLSDIASALRYLHENRIIHRDLKPENIVLQQGEKRLIHKIIDLGYAKELDQGSLCTSFVGTLQYLAPELLEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSEVDIVVSEDLNGAVKFSSSLPFPNNLNSVLAERLEKWLQLMLMWHPRQRGTDPQYGPNGCFRALDDILNLKLVHVLNMVTGTVHTYPVTEDESLQSLKTRIQENTGILETDQELLQKAGLVLLPDKPATQCISDSKTNEGLTLDMDLVFLLDNSKINYETQITPRPPPESVSCILQEPKRNLSFFQLRKVWGQVWHSIQTLKEDCNRLQQGQRAAMMSLLRNNSCLSKMKNAMASTAQQLKAKLDFFKTSIQIDLEKYKEQTEFGITSDKLLLAWREMEQAVEQCGRENDVKHLVERMMALQTDIVDLQRSPMGRKQGGTLDDLEEQARELYRKLREKPRDQRTEGDSQEMVRLLLQAIQSFEKKVRVIYTQLSKTVVCKQKALELLPKVEEVVSLMNEDERTVVRLQEKRQKELWNLLKIACSKVRGPVSGSPDSMNVSRLSHPGQLMSQPSSACDSLPESDKKSEELVAEAHALCSRLESALQDTVKEQDRSFTTLDWSWLQMEDEERCSLEQACD
  
Inhibitor
Name:
BDBM50146943
Synonyms:
CHEMBL3765759
Type:
Small organic molecule
Emp. Form.:
C31H34N4O5S3
Mol. Mass.:
638.82
SMILES:
CN1CCN(CCCOc2ccc(cc2)N2C(=S)S\C(=C/c3ccc(Oc4ccc(NS(C)(=O)=O)cc4)cc3)C2=O)CC1
Structure:
Search PDB for entries with ligand similarity: