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Target
Histone deacetylase 3
Ligand
BDBM50148628
Substrate
n/a
Meas. Tech.
ChEMBL_1556910 (CHEMBL3771935)
IC50
>30000±n/a nM
Citation
 Reddy, DN; Ballante, F; Chuang, T; Pirolli, A; Marrocco, B; Marshall, GR Design and Synthesis of Simplified Largazole Analogues as Isoform-Selective Human Lysine Deacetylase Inhibitors. J Med Chem 59:1613-33 (2016) [PubMed]  Article 
Target
Name:
Histone deacetylase 3
Synonyms:
HD3 | HDAC3 | HDAC3_HUMAN | Histone deacetylase 3 (HDAC3) | Human HDAC3 | RPD3-2 | SMAP45
Type:
Enzyme
Mol. Mass.:
48829.55
Organism:
Homo sapiens (Human)
Description:
O15379
Residue:
428
Sequence:
MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQHDMCRFHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQGATQLNNKICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHGDGVQEAFYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHLFQPVINQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGGGGYTVRNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQYLDQIRQTIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERGPEENYSRPEAPNEFYDGDHDNDKESDVEI
  
Inhibitor
Name:
BDBM50148628
Synonyms:
CHEMBL3769629
Type:
Small organic molecule
Emp. Form.:
C23H36N6O7
Mol. Mass.:
508.5679
SMILES:
[H][C@]12CCCN1C(=O)[C@]1([H])CCCN1C(=O)C[C@@H](NC(=O)[C@@H](NC2=O)C(C)C)C(=O)NCCCC(=O)NO |r|
Structure:
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