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Target
Trypanothione synthetase
Ligand
BDBM50152095
Substrate
n/a
Meas. Tech.
ChEMBL_1565118 (CHEMBL3782440)
IC50
100000±n/a nM
Citation
 Yamasaki, K; Tani, O; Tateishi, Y; Tanabe, E; Namatame, I; Niimi, T; Furukawa, K; Sakashita, H An NMR Biochemical Assay for Fragment-Based Drug Discovery: Evaluation of an Inhibitor Activity on Spermidine Synthase of Trypanosoma cruzi. J Med Chem 59:2261-6 (2016) [PubMed]  Article 
Target
Name:
Trypanothione synthetase
Synonyms:
TRS | TRYS_TRYCC | TryS | Trypanothione synthetase (TryS)
Type:
Enzyme
Mol. Mass.:
73442.57
Organism:
Trypanosoma cruzi
Description:
Q9GT49
Residue:
647
Sequence:
MPTLQSLAVPFGCVQGYAPGGIPAYSNKHESYFSGERSIDGNLFCGFKYQCVEFARRWLFERKSLVLPDVDWAVHIFNLKEVSDARTGKPVRCVAIRNGTAAKPVVDSLLIYPSDDYSPVGHVAAITEVGDKWVRIADQNHRFHKWDANYAAELPLIHEKGVWTILDPLEDEVLKPLGWVTFPDTPDRNPNEPLVLHESLHFKRGELPTLRRLTFTPTSREKDWLDLTNEAEAYFADVCGIDVKNPKLEKASYYQMNRELYLDCAKYGNQLHQMFLEATKFVLGSDELLRLFCIPEEYWPRLRHSWETQPHAITGRFDFAFDEDTQQFKCFEYNADSASTLLECGVIQQKWARSVGLDDGTTYSSGSLVSSRLQLAWEMAEVTGRVHFLIDNDDEEHYTALYVMQHASAAGLETKLCVLFDEFHFDENGVVVDSDGVAVTTVWKTWMWETAIADHQKARVQRGNDWRPTPKDEVRLCDILLGPNWDLRVFEPMWKIIPSNKAILPIIYNKHPDHPALLRASYELTVELQRTGYVRKPIVGRVGRNVTVTEASGDIAAKSDGDFSDRDMVYQELFRLPERDGYYAILGGWVIGDVYCGTGVREDKTIITGLESPFSALRVYQGAQRRPLTHEDLDKAEAAAVGGGLKT
  
Inhibitor
Name:
BDBM50152095
Synonyms:
CHEMBL3779908
Type:
Small organic molecule
Emp. Form.:
C8H8N2S
Mol. Mass.:
164.228
SMILES:
NC1=Nc2ccccc2SC1 |t:1|
Structure:
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