Reaction Details Report a problem with these data
Target
Cannabinoid receptor 1
Ligand
BDBM50152115
Substrate
n/a
Meas. Tech.
ChEMBL_1565145 (CHEMBL3782503)
Ki
>40000±n/a nM
Citation
 Deiana, V; Gómez-Cañas, M; Pazos, MR; Fernández-Ruiz, J; Asproni, B; Cichero, E; Fossa, P; Muñoz, E; Deligia, F; Murineddu, G; García-Arencibia, M; Pinna, GA Tricyclic pyrazoles. Part 8. Synthesis, biological evaluation and modelling of tricyclic pyrazole carboxamides as potential CB2 receptor ligands with antagonist/inverse agonist properties. Eur J Med Chem 112:66-80 (2016) [PubMed]  Article 
Target
Name:
Cannabinoid receptor 1
Synonyms:
CANN6 | CANNABINOID CB1 | CB-R | CB1 | CNR | CNR1 | CNR1_HUMAN | Cannabinoid CB1 receptor | Cannabinoid receptor | Cannabinoid receptor 1 (CB1) | Cannabinoid receptor 1 (brain)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
52868.96
Organism:
Homo sapiens (Human)
Description:
P21554
Residue:
472
Sequence:
MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
  
Inhibitor
Name:
BDBM50152115
Synonyms:
CHEMBL3781252
Type:
Small organic molecule
Emp. Form.:
C31H33Cl2N3O
Mol. Mass.:
534.519
SMILES:
C[C@]12CCC(C1)C(C)(C)C2NC(=O)c1nn(c-2c1CCc1cc(ccc-21)C1CC1)-c1ccc(Cl)cc1Cl |r|
Structure:
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