Target
Oxidized purine nucleoside triphosphate hydrolase
Ligand
BDBM50152125
Substrate
n/a
Meas. Tech.
ChEMBL_1565468 (CHEMBL3782137)
IC50
0.800000±n/a nM
Citation
 Petrocchi, ALeo, EReyna, NJHamilton, MMShi, XParker, CAMseeh, FBardenhagen, JPLeonard, PCross, JBHuang, SJiang, YCardozo, MDraetta, GMarszalek, JRToniatti, CJones, PLewis, RT Identification of potent and selective MTH1 inhibitors. Bioorg Med Chem Lett 26:1503-7 (2016) [PubMed]  Article 
Target
Name:
Oxidized purine nucleoside triphosphate hydrolase
Synonyms:
7,8-dihydro-8-oxoguanine triphosphatase | 8ODP_HUMAN | MTH1 | MutT homolog 1 protein (MTH1) | NUDT1
Type:
Protein
Mol. Mass.:
22514.81
Organism:
Homo sapiens (Human)
Description:
P36639
Residue:
197
Sequence:
MYWSNQITRRLGERVQGFMSGISPQQMGEPEGSWSGKNPGTMGASRLYTLVLVLQPQRVLLGMKKRGFGAGRWNGFGGKVQEGETIEDGARRELQEESGLTVDALHKVGQIVFEFVGEPELMDVHVFCTDSIQGTPVESDEMRPCWFQLDQIPFKDMWPDDSYWFPLLLQKKKFHGYFKFQGQDTILDYTLREVDTV
  
Inhibitor
Name:
BDBM50152125
Synonyms:
CHEMBL3781316
Type:
Small organic molecule
Emp. Form.:
C11H10Cl2N4
Mol. Mass.:
269.13
SMILES:
CNc1cc(nc(N)n1)-c1cccc(Cl)c1Cl
Structure:
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