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Target
D(4) dopamine receptor
Ligand
BDBM50156936
Substrate
n/a
Meas. Tech.
ChEMBL_1571915 (CHEMBL3796307)
Ki
37±n/a nM
Citation
 Witt, JO; McCollum, AL; Hurtado, MA; Huseman, ED; Jeffries, DE; Temple, KJ; Plumley, HC; Blobaum, AL; Lindsley, CW; Hopkins, CR Synthesis and characterization of a series of chiral alkoxymethyl morpholine analogs as dopamine receptor 4 (D4R) antagonists. Bioorg Med Chem Lett 26:2481-8 (2016) [PubMed]  Article 
Target
Name:
D(4) dopamine receptor
Synonyms:
D(2C) dopamine receptor | DOPAMINE D4 | DOPAMINE D4.2 | DOPAMINE D4.4 | DRD4 | DRD4_HUMAN | Dopamine D4 receptor
Type:
Enzyme
Mol. Mass.:
48373.19
Organism:
Homo sapiens (Human)
Description:
P21917
Residue:
419
Sequence:
MGNRSTADADGLLAGRGPAAGASAGASAGLAGQGAAALVGGVLLIGAVLAGNSLVCVSVATERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQGGAWLLSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIGATWLLSAAVAAPVLCGLNDVRGRDPAVCRLEDRDYVVYSSVCSFFLPCPLMLLLYWATFRGLQRWEVARRAKLHGRAPRRPSGPGPPSPTPPAPRLPQDPCGPDCAPPAPGLPRGPCGPDCAPAAPSLPQDPCGPDCAPPAPGLPPDPCGSNCAPPDAVRAAALPPQTPPQTRRRRRAKITGRERKAMRVLPVVVGAFLLCWTPFFVVHITQALCPACSVPPRLVSAVTWLGYVNSALNPVIYTVFNAEFRNVFRKALRACC
  
Inhibitor
Name:
BDBM50156936
Synonyms:
CHEMBL3793906
Type:
Small organic molecule
Emp. Form.:
C20H21ClN2O2
Mol. Mass.:
356.846
SMILES:
Clc1ccc2[nH]cc(CN3CCO[C@H](COc4ccccc4)C3)c2c1 |r|
Structure:
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