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TargetExcitatory amino acid transporter 1
LigandBDBM50252049
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1568619
IC50>300000±n/a nM
Citation Huynh, THErichsen, MNTora, ASGoudet, CSagot, EAssaf, ZThomsen, CBrodbeck, RStensbøl, TBBjørn-Yoshimoto, WENielsen, BPin, JPGefflaut, TBunch, L New 4-Functionalized Glutamate Analogues Are Selective Agonists at Metabotropic Glutamate Receptor Subtype 2 or Selective Agonists at Metabotropic Glutamate Receptor Group III. J Med Chem59:914-24 (2016) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Excitatory amino acid transporter 1
Name:Excitatory amino acid transporter 1
Synonyms:Excitatory Amino Acid EAAT1
Type:Enzyme Catalytic Domain
Mol. Mass.:59577.19
Organism:Homo sapiens (Human)
Description:Excitatory Amino Acid EAAT1 0 HUMAN::P43003
Residue:542
Sequence:
MTKSNGEEPKMGGRMERFQQGVRKRTLLAKKKVQNITKEDVKSYLFRNAFVLLTVTAVIV
GTILGFTLRPYRMSYREVKYFSFPGELLMRMLQMLVLPLIISSLVTGMAALDSKASGKMG
MRAVVYYMTTTIIAVVIGIIIVIIIHPGKGTKENMHREGKIVRVTAADAFLDLIRNMFPP
NLVEACFKQFKTNYEKRSFKVPIQANETLVGAVINNVSEAMETLTRITEELVPVPGSVNG
VNALGLVVFSMCFGFVIGNMKEQGQALREFFDSLNEAIMRLVAVIMWYAPVGILFLIAGK
IVEMEDMGVIGGQLAMYTVTVIVGLLIHAVIVLPLLYFLVTRKNPWVFIGGLLQALITAL
GTSSSSATLPITFKCLEENNGVDKRVTRFVLPVGATINMDGTALYEALAAIFIAQVNNFE
LNFGQIITISITATAASIGAAGIPQAGLVTMVIVLTSVGLPTDDITLIIAVDWFLDRLRT
TTNVLGDSLGAGIVEHLSRHELKNRDVEMGNSVIEENEMKKPYQLIAQDNETEKPIDSET
KM
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50252049
NameBDBM50252049
Synonyms:(1S,3R)-1-aminopentane-1,3,5-tricarboxylic acid | (2S,4R)-4-(3-Hydroxy-3-oxopropyl)glutamic Acid | CHEMBL482081
TypeSmall organic molecule
Emp. Form.C8H13NO6
Mol. Mass.219.1919
SMILESN[C@@H](C[C@@H](CCC(O)=O)C(O)=O)C(O)=O |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a