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Target
Induced myeloid leukemia cell differentiation protein Mcl-1
Ligand
BDBM50160011
Substrate
n/a
Meas. Tech.
ChEMBL_1565814 (CHEMBL3789421)
Ki
<10±n/a nM
Citation
 Pelz, NF; Bian, Z; Zhao, B; Shaw, S; Tarr, JC; Belmar, J; Gregg, C; Camper, DV; Goodwin, CM; Arnold, AL; Sensintaffar, JL; Friberg, A; Rossanese, OW; Lee, T; Olejniczak, ET; Fesik, SW Discovery of 2-Indole-acylsulfonamide Myeloid Cell Leukemia 1 (Mcl-1) Inhibitors Using Fragment-Based Methods. J Med Chem 59:2054-66 (2016) [PubMed]  Article 
Target
Name:
Induced myeloid leukemia cell differentiation protein Mcl-1
Synonyms:
BCL2L3 | Bcl-2-like protein 3 | Bcl-2-like protein 3 (Mcl-1) | Bcl-2-related protein EAT/mcl1 | Bcl2-L-3 | Induced myeloid leukemia cell differentiation protein (Mcl-1) | MCL1 | MCL1_HUMAN | Mcl-1 | Myeloid Cell factor-1 (Mcl-1) | Myeloid cell leukemia sequence 1 (BCL2-related) | mcl1/EAT
Type:
Membrane; Single-pass membrane protein
Mol. Mass.:
37332.87
Organism:
Homo sapiens (Human)
Description:
Q07820
Residue:
350
Sequence:
MFGLKRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATEKEASARREIGGGEAGAVIGGSAGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLLFFAPTRRAAPLEEMEAPAADAIMSPEEELDGYEPEPLGKRPAVLPLLELVGESGNNTSTDGSLPSTPPPAEEEEDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYLIR
  
Inhibitor
Name:
BDBM50160011
Synonyms:
CHEMBL3786622
Type:
Small organic molecule
Emp. Form.:
C32H29Cl2N3O4S
Mol. Mass.:
622.561
SMILES:
Cc1cc(OCCCc2c([nH]c3c(c(Cl)ccc23)-c2cccnc2C)C(=O)NS(=O)(=O)c2ccccc2)cc(C)c1Cl |(9.43,-8.27,;8.22,-8.02,;7.74,-6.56,;6.23,-6.24,;5.75,-4.78,;4.24,-4.47,;3.75,-3.01,;2.24,-2.7,;1.76,-1.24,;2.66,.02,;1.76,1.24,;.3,.77,;-1.03,1.55,;-2.38,.77,;-3.45,1.38,;-2.38,-.77,;-1.03,-1.55,;.3,-.77,;-1.02,3.09,;.32,3.85,;.33,5.39,;-.99,6.17,;-2.34,5.42,;-2.35,3.88,;-3.42,3.27,;4.2,.04,;4.83,-1.02,;4.95,1.38,;6.49,1.4,;7.12,.35,;5.89,.33,;7.24,2.75,;8.78,2.77,;9.54,4.11,;8.75,5.44,;7.21,5.42,;6.46,4.07,;5.21,-7.39,;5.69,-8.86,;4.87,-9.77,;7.2,-9.17,;7.58,-10.34,)|
Structure:
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