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Target
Glutamate carboxypeptidase 2
Ligand
BDBM17659
Substrate
n/a
Meas. Tech.
ChEMBL_1566974 (CHEMBL3791236)
IC50
52±n/a nM
Citation
 Genady, AR; Janzen, N; Banevicius, L; El-Gamal, M; El-Zaria, ME; Valliant, JF Preparation and Evaluation of Radiolabeled Antibody Recruiting Small Molecules That Target Prostate-Specific Membrane Antigen for Combined Radiotherapy and Immunotherapy. J Med Chem 59:2660-73 (2016) [PubMed]  Article 
Target
Name:
Glutamate carboxypeptidase 2
Synonyms:
FGCP | FOLH | FOLH1 | FOLH1_HUMAN | Folate hydrolase 1 | Folylpoly-gamma-glutamate carboxypeptidase | Glutamate carboxypeptidase 2 | Glutamate carboxypeptidase II | Membrane glutamate carboxypeptidase | N-acetylated-alpha-linked acidic dipeptidase I | NAALAD1 | NAALADase I | PSM | PSMA | Prostate-specific membrane antigen | Pteroylpoly-gamma-glutamate carboxypeptidase | mGCP
Type:
PROTEIN
Mol. Mass.:
84333.66
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1497035
Residue:
750
Sequence:
MWNLLHETDSAVATARRPRWLCAGALVLAGGFFLLGFLFGWFIKSSNEATNITPKHNMKAFLDELKAENIKKFLYNFTQIPHLAGTEQNFQLAKQIQSQWKEFGLDSVELAHYDVLLSYPNKTHPNYISIINEDGNEIFNTSLFEPPPPGYENVSDIVPPFSAFSPQGMPEGDLVYVNYARTEDFFKLERDMKINCSGKIVIARYGKVFRGNKVKNAQLAGAKGVILYSDPADYFAPGVKSYPDGWNLPGGGVQRGNILNLNGAGDPLTPGYPANEYAYRRGIAEAVGLPSIPVHPIGYYDAQKLLEKMGGSAPPDSSWRGSLKVPYNVGPGFTGNFSTQKVKMHIHSTNEVTRIYNVIGTLRGAVEPDRYVILGGHRDSWVFGGIDPQSGAAVVHEIVRSFGTLKKEGWRPRRTILFASWDAEEFGLLGSTEWAEENSRLLQERGVAYINADSSIEGNYTLRVDCTPLMYSLVHNLTKELKSPDEGFEGKSLYESWTKKSPSPEFSGMPRISKLGSGNDFEVFFQRLGIASGRARYTKNWETNKFSGYPLYHSVYETYELVEKFYDPMFKYHLTVAQVRGGMVFELANSIVLPFDCRDYAVVLRKYADKIYSISMKHPQEMKTYSVSFDSLFSAVKNFTEIASKFSERLQDFDKSNPIVLRMMNDQLMFLERAFIDPLGLPDRPFYRHVIYAPSSHNKYAGESFPGIYDALFDIESKVDPSKAWGEVKRQIYVAAFTVQAAAETLSEVA
  
Inhibitor
Name:
BDBM17659
Synonyms:
(R,S)-2-phosphonomethylpentanedioic acid | 2-(phosphonomethyl)pentanedioic acid | 2-PMPA | CHEMBL47009 | US10894807, ID P009 | pentanedioic acid analogue, (RS)-1
Type:
Small organic molecule
Emp. Form.:
C6H11O7P
Mol. Mass.:
226.1211
SMILES:
OC(=O)CCC(CP(O)(O)=O)C(O)=O
Structure:
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