Target
Histone deacetylase 8
Ligand
BDBM50164516
Substrate
n/a
Meas. Tech.
ChEMBL_1575027 (CHEMBL3803862)
IC50
29±n/a nM
Citation
 Heimburg, TChakrabarti, ALancelot, JMarek, MMelesina, JHauser, ATShaik, TBDuclaud, SRobaa, DErdmann, FSchmidt, MRomier, CPierce, RJJung, MSippl, W Structure-Based Design and Synthesis of Novel Inhibitors Targeting HDAC8 from Schistosoma mansoni for the Treatment of Schistosomiasis. J Med Chem 59:2423-35 (2016) [PubMed]  Article 
Target
Name:
Histone deacetylase 8
Synonyms:
HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8
Type:
Enzyme
Mol. Mass.:
41749.60
Organism:
Homo sapiens (Human)
Description:
Q9BY41
Residue:
377
Sequence:
MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV
  
Inhibitor
Name:
BDBM50164516
Synonyms:
CHEMBL3800057
Type:
Small organic molecule
Emp. Form.:
C17H18N2O4
Mol. Mass.:
314.3358
SMILES:
CC(C)Oc1ccc(cc1NC(=O)c1ccccc1)C(=O)NO
Structure:
Search PDB for entries with ligand similarity: