Reaction Details Report a problem with these data
Target
P2Y purinoceptor 12
Ligand
BDBM50167270
Substrate
n/a
Meas. Tech.
ChEMBL_1573761 (CHEMBL3802945)
IC50
0.794328±n/a nM
Citation
 Zetterberg, F; Svensson, P State of affairs: Design and structure-activity relationships of reversible P2Y12 receptor antagonists. Bioorg Med Chem Lett 26:2739-2754 (2016) [PubMed]  Article 
Target
Name:
P2Y purinoceptor 12
Synonyms:
ADP-glucose receptor | ADPG-R | HORK3 | P2RY12 | P2T(AC) | P2Y purinoceptor 12 | P2Y(AC) | P2Y(ADP) | P2Y(cyc) | P2Y12 | P2Y12 platelet ADP receptor | P2Y12_HUMAN | Purinergic receptor P2Y12 | SP1999
Type:
Enzyme
Mol. Mass.:
39458.48
Organism:
Homo sapiens (Human)
Description:
Q9H244
Residue:
342
Sequence:
MQAVDNLTSAPGNTSLCTRDYKITQVLFPLLYTVLFFVGLITNGLAMRIFFQIRSKSNFIIFLKNTVISDLLMILTFPFKILSDAKLGTGPLRTFVCQVTSVIFYFTMYISISFLGLITIDRYQKTTRPFKTSNPKNLLGAKILSVVIWAFMFLLSLPNMILTNRQPRDKNVKKCSFLKSEFGLVWHEIVNYICQVIFWINFLIVIVCYTLITKELYRSYVRTRGVGKVPRKKVNVKVFIIIAVFFICFVPFHFARIPYTLSQTRDVFDCTAENTLFYVKESTLWLTSLNACLDPFIYFFLCKSFRNSLISMLKCPNSATSLSQDNRKKEQDGGDPNEETPM
  
Inhibitor
Name:
BDBM50167270
Synonyms:
CHEMBL1160364
Type:
Small organic molecule
Emp. Form.:
C16H20Cl2F6N5O12P3S
Mol. Mass.:
784.239
SMILES:
O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(=O)OP(O)(=O)C(Cl)(Cl)P(O)(O)=O)n1cnc2c(NCC(F)(F)F)nc(SCCC(F)(F)F)nc12 |r|
Structure:
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